Evidence map›Paper›PMID 40999925›Full record

SynthesisBJOG : an international journal of obstetrics and gynaecology2026

Intrapartum Antibiotic Prophylaxis and Child Health Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.

Maedeh Moradi, Jessica A Grieger, Xiao Tong Teong, Leonie K Heilbronn

Abstract readSystematic ReviewMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BJOG : an international journal of obstetrics and gynaecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maedeh MoradiAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0001-8941-6982
Jessica A GriegerAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0003-1515-948X
Xiao Tong TeongAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
Leonie K HeilbronnAdelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.

Funding

The university of Adelaide
6 · The paper itself

Abstract

backgroundWith increasing use of intrapartum antibiotic prophylaxis (IAP) for the prevention of early-onset Group B streptococcus (GBS) infections, there is concern about its long-term consequences on child health.

objectivesTo synthesise the evidence of IAP exposure on autoimmune-related diseases, obesity in childhood and microbial diversity in infants. SEARCH STRATEGY: PubMed, Web of Science, Emcare, Embase and Scopus were searched from inception until 17 July 2025 for related observational studies. SELECTION CRITERIA: The exposure group comprised mothers with full-term vaginal deliveries who underwent GBS screening and received IAP, while the comparator group included mothers with full-term vaginal deliveries with GBS-negative results and no IAP exposure. DATA COLLECTION AND ANALYSIS: Results were pooled using fixed or random-effects meta-analysis based on heterogeneity assessed by the I MAIN

resultsSixteen studies were eligible to be included in the meta-analysis. IAP exposure was associated with an increased risk of autoimmune-related disease (6 studies, relative risks (RRs) = 1.73; 95% confidence interval [CI]: 1.08-2.78; I

conclusionIAP exposure is associated with an increased risk of autoimmune-related disease and a modest increase in child BMI. TRAIL REGISTRATION: PROSPERO (CRD42023493413).

Indexed as

Anti-Bacterial AgentsAntibiotic ProphylaxisChild HealthPregnancy Complications, InfectiousStreptococcal InfectionsAutoimmune DiseasesFemaleHumansInfantInfant, NewbornObservational Studies as TopicPediatric ObesityPregnancyStreptococcus agalactiaeAnti-Bacterial Agentsautoimmune diseasechild obesitygut microbiotaintrapartum antibiotic prophylaxis

Identifiers

PMID40999925
PMCPMC12884238

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.