Evidence map›Paper›PMID 40999903›Full record

ArticleActa biochimica et biophysica Sinica2025

Single-cell transcriptomics reveals apolipoprotein A4-mediated metabolic-immune reprogramming in lymphocytes during early obesity-related chronic kidney disease.

Yang Wei, Ting Zhang, Yingying Jin, Xiaohuan Liu, Jinting Zhou, Na Huang, Yiying Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yang WeiDepartment of Pathology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Ting ZhangCore Research Laboratory, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Yingying JinDepartment of Radiation Therapy, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Xiaohuan LiuNational & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, Precision Medical Institute, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Jinting ZhouKey Laboratory of the Ministry of Public Health for Forensic Sciences, Western China Science & Technology Innovation Harbor, Xi'an 710100, China.
Na HuangNational & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, Precision Medical Institute, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Yiying WangThe School of Public Health, Hebei Medical University, Shijiazhuang 050011, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity-induced metabolic inflammation is a key driver of chronic kidney disease (CKD), with immune dysregulation, particularly among lymphocytes, contributing to early disease pathology. To explore the role of apolipoprotein A4 (Apoa4) in regulating immune cell metabolism and function, we establish high-fat diet-induced obese (DIO) models using wild-type and

Indexed as

Apoa4chronic kidney diseaseimmunemetabolismobesitysingle-cell RNA sequencing

Identifiers

PMID40999903
PMCPMC12747934

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.