Evidence map›Paper›PMID 40999902›Full record

ArticleActa biochimica et biophysica Sinica2025

KDM4A regulates microglial polarization after ischemic stroke by regulating SPINK5 signaling.

Xiaoli Min, Lei Xian, Ting Liu, Mengze Wang, Qing Zhao, Jiayi Hu, Rui Jing

Abstract read
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoli MinDepartment of Cerebrovascular Diseases, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China.
Lei XianDepartment of Cerebrovascular Diseases, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China.
Ting LiuDepartment of Neurology, the Fourth Affiliated Hospital of Xinjiang Medical University, Xinjing 830054, China.
Mengze WangDepartment of Neurosurgery, Affiliated Children's Hospital of Kunming Medical University, Kunming 650103, China.
Qing ZhaoDepartment of Cerebrovascular Diseases, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China.
Jiayi HuDepartment of Cerebrovascular Diseases, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China.
Rui JingDepartment of Cerebrovascular Diseases, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microglia/macrophage polarization is a crucial factor in inflammatory processes following ischemic stroke (IS). This study explores the molecular mechanisms through which lysine-specific histone demethylase 4 (KDM4A) regulates microglial polarization postischemic stroke. IS models are established

Indexed as

apoptosisischemic strokeKDM4Amicroglial polarizationSPINK5

Identifiers

PMID40999902
PMCPMC13107017

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.