Evidence map›Paper›PMID 40999879›Full record

ArticleOncoimmunology2025

Characterization of the immune landscape in healthy mouse prostate and during prostate cancer progression.

Despoina Pervizou, Joanna De Chiara, Lionel Spinelli, Maïa Nestor-Martin, Lionel Chasson, Kateryna Len-Tayon, Darya Yanushko, Frédéric Fiore, Marc Bajénoff, Bernard Malissen and 3 more

Abstract read
In one paragraph

Article in Oncoimmunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Despoina PervizouAix-Marseille Université, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.ORCID 0009-0007-4178-8374
Joanna De ChiaraAix-Marseille Université, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.ORCID 0009-0005-3087-9997
Lionel SpinelliAix-Marseille Université, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.ORCID 0000-0001-9228-8141
Maïa Nestor-MartinAix-Marseille Université, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.ORCID 0009-0001-6422-2724
Lionel ChassonAix-Marseille Université, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
Kateryna Len-TayonInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Functional Genomics and Cancer, Illkirch, France.ORCID 0000-0002-5397-391X
Darya YanushkoInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Functional Genomics and Cancer, Illkirch, France.ORCID 0000-0001-6223-9015
Frédéric FioreCentre d'Immunophénomique, Aix Marseille Université, INSERM, CNRS, Marseille, France.ORCID 0000-0001-7955-6594
Marc BajénoffAix-Marseille Université, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.ORCID 0000-0002-0702-8319
Bernard MalissenAix-Marseille Université, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.ORCID 0000-0003-1340-9342
Daniel MetzgerInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Functional Genomics and Cancer, Illkirch, France.ORCID 0000-0002-5555-046X
Gilles LavernyInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Functional Genomics and Cancer, Illkirch, France.ORCID 0000-0002-2666-6877
Sandrine HenriAix-Marseille Université, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.ORCID 0000-0002-8980-9193

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immune landscape of healthy prostate and its alterations during prostate cancer (PCa) progression remain poorly characterized. Using scRNA-sequencing and multiparametric flow-cytometry analysis, we comprehensively characterized immune cells in wild-type and PTEN

Indexed as

ProstateProstatic NeoplasmsAnimalsCD8-Positive T-LymphocytesDisease Models, AnimalDisease ProgressionHumansMaleMiceMice, KnockoutNeutrophilsPTEN PhosphohydrolaseTumor-Associated MacrophagesTumor MicroenvironmentPTEN PhosphohydrolasePten protein, mouseexhausted CD8+ T cellsmultiparametric flow cytometryProstatePTEN(i)pe−/− prostate cancer murine modelresident macrophage subsetsscRNA-seqTrem2+ tumor-associated-macrophages (TAM)tumor-associated-neutrophils (TAN)

Identifiers

PMID40999879
PMCPMC12477881

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.