Evidence map›Paper›PMID 40999829›Full record

SynthesisJournal of gastroenterology and hepatology2025

Epidemiology of Metabolic Dysfunction-Associated Steatotic Liver Disease in South Asian Ethnicities: A Systematic Review and Meta-Analysis.

Michael James, Melanie Smuk, Naheeda Rahman, Georgia Black, William Alazawi

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Periodontitis and MASLD: a narrative review of the direct oral-hepatic pathway.Frontiers in cellular and infection microbiology · 2026
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael JamesCentre for Immunobiology, Blizard Institute, Queen Mary University of London, London, UK.ORCID https://orcid.org/0000-0003-1268-4481
Melanie SmukCentre for Genomics and Child Health, Blizard Institute, Queen Mary University of London, London, UK.
Naheeda RahmanCentre for Immunobiology, Blizard Institute, Queen Mary University of London, London, UK.
Georgia BlackCentre of Prevention, Detection and Diagnosis, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
William AlazawiCentre for Immunobiology, Blizard Institute, Queen Mary University of London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsPeople of South Asian ethnicities are at increased risk of metabolic syndrome, but the epidemiology of metabolic dysfunction-associated steatotic liver disease (MASLD) in this population remains poorly understood. This systematic review and meta-analysis assesses the prevalence, cross-sectional severity, and clinically relevant endpoints of MASLD in this group.

methodsStudies from January 2002 to November 2023 across PubMed, Embase, Ovid, and Cochrane databases, meeting inclusion criteria, were included. We performed a random effects meta-analysis to calculate pooled prevalence and proportions.

resultsSixty-two articles met inclusion criteria (n = 40 745). Fifty-three were based in India, 4 in Sri Lanka, 3 in Pakistan, and 2 in Bangladesh. The pooled prevalence of MASLD in studies that did not select for T2DM status was 34.7% (95% CI 29.0%-40.5%, I

conclusionsMASLD prevalence in South Asian ethnicities is high, and the proportion of people with advanced fibrosis may be higher compared with multiethnic populations, though high-quality longitudinal studies are needed to better understand the epidemiology of this cohort.

Indexed as

Fatty LiverMetabolic SyndromeSouth Asian PeopleBangladeshDiabetes Mellitus, Type 2FemaleHumansIndiaMalePakistanPrevalenceSeverity of Illness IndexSri LankaethnicityMASLDmetabolicsouth Asian

Identifiers

PMID40999829
PMCPMC12666614

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.