SynthesisPharmacoepidemiology and drug safety2025
Warfarin-Associated Bleeding and Thromboembolic Events in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.
Synthesis in Pharmacoepidemiology and drug safety, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Warfarin-Associated Bleeding and Thromboembolic Events in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.Pharmacoepidemiology and drug safety · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWarfarin use in Sub-Saharan Africa is associated with elevated risks of thromboembolic events and bleeding, but precise prevalence estimates are lacking. This systematic review and meta-analysis aimed to quantify the prevalence of bleeding and thromboembolic events among patients on warfarin in Sub-Saharan Africa.
methodsComprehensive searches were conducted in MEDLINE via Ovid, PubMed, Embase via Ovid, Scopus, and Google Scholar to identify relevant studies. Primary outcomes included major and minor bleeding events, while thromboembolic events were secondary outcomes. Meta-analysis was conducted using RStudio version 4.3.3 with the meta and metaprop packages. Proportions were transformed using the Freeman-Tukey double arcsine method, and meta-regression was performed with the metafor package's escal, rma, and res functions. Publication bias was assessed via funnel plots and Egger's test, with a p value < 0.05 indicating potential bias. Sensitivity analysis was conducted through leave-one-out analysis. The review was performed in adherence to PRISMA guidelines.
resultsWe identified 10 observational studies for inclusion in this systematic review and meta-analysis. Egger's test indicated no publication bias. Meta-regression analysis showed that moderators (publication year, sample size, setting, and follow-up duration) did not significantly impact bleeding risk. The pooled prevalence of major and minor bleeding was 18% (95% CI: 0.10-0.27; I
conclusionWarfarin therapy in Sub-Saharan Africa is associated with considerable bleeding and thromboembolic risks. The robustness of these findings was confirmed through meta-regression and sensitivity analyses, underscoring the need for improved therapeutic monitoring and safety strategies in this population.
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