Evidence map›Paper›PMID 40999722›Full record

ArticleInternational endodontic journal2026

Biological Advantages of Calcium Hypochlorite Solution Over Sodium Hypochlorite for Regenerative Endodontic Procedures: An Ex Vivo and In Vitro Study on Human Apical Papilla.

Hernán Coaguila-Llerena, Ellen Rabelo Ferraz, Bárbara Roma Mendes, Luana Raphael da Silva, Carlos Rossa Júnior, Paulo Sérgio Cerri, Gisele Faria

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International endodontic journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hernán Coaguila-LlerenaSchool of Dentistry, Araraquara, Department of Restorative Dentistry, São Paulo State University (UNESP), São Paulo, Brazil.ORCID https://orcid.org/0000-0002-9991-718X
Ellen Rabelo FerrazSchool of Dentistry, Araraquara, Department of Restorative Dentistry, São Paulo State University (UNESP), São Paulo, Brazil.ORCID https://orcid.org/0009-0007-0906-8414
Bárbara Roma MendesSchool of Dentistry, Araraquara, Department of Restorative Dentistry, São Paulo State University (UNESP), São Paulo, Brazil.ORCID https://orcid.org/0000-0002-7694-4732
Luana Raphael da SilvaSchool of Dentistry, Araraquara, Department of Restorative Dentistry, São Paulo State University (UNESP), São Paulo, Brazil.ORCID https://orcid.org/0000-0001-5560-3587
Carlos Rossa JúniorSchool of Dentistry, Araraquara, Department of Oral Diagnosis and Surgery, São Paulo State University (UNESP), São Paulo, Brazil.ORCID https://orcid.org/0000-0003-1705-5481
Paulo Sérgio CerriSchool of Dentistry, Araraquara, Department of Morphology and Paediatric Dentistry, Laboratory of Histology and Embryology, São Paulo State University (UNESP), São Paulo, Brazil.ORCID https://orcid.org/0000-0001-5756-5828
Gisele FariaSchool of Dentistry, Araraquara, Department of Restorative Dentistry, São Paulo State University (UNESP), São Paulo, Brazil.ORCID https://orcid.org/0000-0001-7030-3718

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 9903Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/02070-2Fundação de Amparo à Pesquisa do Estado de São Paulo 22/07823-1Fundação de Amparo à Pesquisa do Estado de São Paulo 22/08004-4Universidade Estadual Paulista 04/2022
6 · The paper itself

Abstract

aimCalcium hypochlorite [Ca(OCl) METHODOLOGY: Ex vivo, three AP samples per group were exposed to 1.5% Ca(OCl)

resultsEx vivo, marked loss of both cells and extracellular matrix components was observed in the outer layer of AP samples, particularly in the NaOCl and Ca(OCl)

conclusionsCa(OCl)

Indexed as

Calcium CompoundsDental PapillaRegenerative EndodonticsRoot Canal IrrigantsSodium HypochloriteCell DifferentiationCell ProliferationCells, CulturedCell SurvivalChemotaxisEdetic AcidHumansIn Vitro TechniquesOsteogenesisCalcium Compoundscalcium hypochloriteEdetic AcidRoot Canal IrrigantsSodium Hypochloritecalcium hypochloritedental papillaregenerative endodonticssodium hypochlorite

Identifiers

PMID40999722
PMCPMC12701743

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.