ArticleCurrent medical imaging2025
Reduced Field-of-view Diffusion-Weighted Magnetic Resonance Imaging for Detecting Early Gastric Cancer: A Pilot Study Comparing Diagnostic Performance with MDCT and fFOV DWI.
Article in Current medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionEarly detection of gastric cancer remains challenging for many of the current imaging techniques. Recent advancements in reduced field-of-view (rFOV) diffusion-weighted imaging (DWI) have shown promise in improving the visualization of small anatomical structures. This study aimed to evaluate and compare the diagnostic performance of rFOV DWI with multi-detector computed tomography (MDCT) and conventional full field of view (fFOV) DWI for detecting early gastric cancer (EGC).
methodsThis retrospective study included 43 patients with pathologically confirmed EGC. All participants underwent pre-treatment imaging, including CT scans and MRI with a prototype rFOV DWI and conventional fFOV DWI at 3 Tesla. Quantitative (signal-to-noise ratio [SNR], contrast-to-noise ratio [CNR]) and qualitative (subjective image quality) assessments were performed. Diagnostic performance was evaluated using receiver operating characteristic (ROC) curves and area-under-the-curve (AUC) analysis.
resultsrFOV DWI demonstrated significantly higher SNR and CNR compared with fFOV DWI (P < 0.05). Subjective image quality scores were also superior for rFOV DWI (P < 0.05). In lesion detection, rFOV DWI showed higher sensitivity (0.705) than CT (0.636) and fFOV DWI (0.523). ROC analysis revealed that rFOV DWI had a higher AUC (0.829, 95% CI [0.764, 0.882]) than fFOV DWI (0.734, 95% CI [0.661, 0.798], P = 0.02) and a modest improvement over CT (0.799, 95% CI [0.731, 0.856], P = 0.51). DISCUSSION: The findings suggest that rFOV DWI provides superior image quality and diagnostic accuracy for EGC detection compared with conventional fFOV DWI. While it showed a trend toward better performance than CT, further studies with larger cohorts are needed to validate these results.
conclusionrFOV DWI offers improved image quality and diagnostic performance for early gastric cancer detection compared with fFOV DWI, with a potential advantage over CT. This technique may enhance early diagnosis and clinical decision-making in gastric cancer management.
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