Evidence map›Paper›PMID 40999605›Full record

ReviewCurrent pharmaceutical design2026

Potential Role of Natural Oil in the Management of Diabetic Neuropathy- A Review.

Partha Pratim Dutta, Shiny Ahmed, Lunasmrita Saikia, Douglas Law, Seydur Rahman, Shila Kumari Singh, Saikat Sen, Manash Pratim Pathak, Pal Gogoi, Manish Kumar Gautam and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pharmaceutical design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Partha Pratim DuttaFaculty of Pharmaceutical Science, Assam Down Town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, 781026, Assam, India.
Shiny AhmedFaculty of Pharmaceutical Science, Assam Down Town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, 781026, Assam, India.
Lunasmrita SaikiaFaculty of Pharmaceutical Science, Assam Down Town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, 781026, Assam, India.
Douglas LawFaculty of Health and Life Sciences, Inti International University, 71800, Nilai, Negeri Sembilan, Malaysia.
Seydur RahmanFaculty of Sciences, Assam Down Town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, 781026, Assam, India.
Shila Kumari SinghFaculty of Paramedical Sciences, Assam Down Town University, Sankar Madhab Path, Gandhi Nagar Panikhaiti, Guwahati, 781026, Assam, India.
Saikat SenFaculty of Pharmaceutical Science, Assam Down Town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, 781026, Assam, India.
Manash Pratim PathakFaculty of Pharmaceutical Science, Assam Down Town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, 781026, Assam, India.
Pal GogoiFaculty of Pharmaceutical Science, Assam Down Town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, 781026, Assam, India.
Manish Kumar GautamFaculty of Pharmaceutical Science, Assam Down Town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, 781026, Assam, India.
Narayan Chandra TalukdarFaculty of Sciences, Assam Down Town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, 781026, Assam, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDiabetic neuropathy (DN) is a common complication of diabetes with limited therapeutic options. Given its complex pathophysiology involving oxidative stress, inflammation, and impaired nerve function, there is increasing interest in complementary therapies. This review aims to summarize the potential use of natural oils, both as dietary supplements and topical agents, for the prevention and management of DN.

methodsA systematic literature search was conducted using databases such as SciFinder and PubMed for studies published from 1988 to January 2024. The search employed keywords including "diabetic neuropathy," "natural oils," and "bioactive constituents." Relevant studies involving preclinical and clinical evaluation of natural oils or their active compounds in DN were selected, analyzed, and categorized based on the type of oil, mode of application, and mechanism of action.

resultsSeveral natural oils of plant and animal origin demonstrated protective and therapeutic effects against DN in both animal models and limited clinical settings. Their beneficial effects were attributed to antiinflammatory and antioxidant properties, enhanced nerve conduction velocity, and modulation of vascular and neurotrophic factors. Both oral and topical applications contributed to symptom improvement. DISCUSSION: Due to the involvement of various signalling pathways and complex pathophysiology, DN has long been a condition with few acceptable treatment options. Although several natural oils have demonstrated activity against DN, very few clinical studies have been conducted to explore their therapeutic potential fully.

conclusionNatural oils represent a potential complementary strategy for managing DN. However, more rigorous clinical investigations are essential to confirm their safety, efficacy, and translational value.

Indexed as

Anti-Inflammatory AgentsAntioxidantsDiabetic NeuropathiesPlant OilsAnimalsDietary SupplementsHumansAnti-Inflammatory AgentsAntioxidantsPlant Oilsmanagement therapynatural oilnerve conduction velocityneural blood flowSignalling pathwayvascular alterations

Identifiers

PMID40999605

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.