ArticleBrain and behavior2025
Correlation of 3D MRI-Derived Adenohypophysis Volume With Height and Peak GH in Peripubertal Children.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Correlation of 3D MRI-Derived Adenohypophysis Volume With Height and Peak GH in Peripubertal Children.Brain and behavior · 2025Article
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6 authors.
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Abstract
purposeTo investigate correlations between adenohypophysis volume (aPV) quantified by 3D CUBE T1 MRI, height, and peak GH levels (GH max), and evaluate its clinical utility. MATERIALS AND
methodsA total of 380 children (3-12 years) old with suspected growth and development disorders enrolled from May 2020 to July 2022. All of them underwent 3.0T pituitary MRI with 3D CUBE T1WI, serological testing, growth hormone stimulation testing, and aPV and peak GH levels were also measured. Pearson and partial correlation analysis assessed relationships between aPV, height, and peak GH.
resultsStrong aPV correlations with weight (r = 0.603, p < 0.001), age (r = 0.575, p < 0.001), and height (r = 0.665, p < 0.001) were observed in adolescent children. There was no significant correlation between aPV and peak GH (r = 0.083, p = 0.105), and between peak GH value and height (r = -0.108, p = 0.036) in adolescent children. No gender-based aPV difference was observed using the Mann-Whitney U test (p > 0.05). After covariate adjustment (age, gender, weight), there were a significant aPV and height correlation (r = 0.250, p < 0.001), a significant aPV and peak GH correlation (r = 0.246, p < 0.001), and a significant peak GH and height correlation (r = 0.176, p < 0.001).
conclusionsAfter controlling confounders, the correlation between the aPV and height exceeds the correlation between peak GH and height. aPV reflects not only GH secretion but also integrated endocrine regulation of growth thorough multiple hormones. 3D CUBE T1 volumetry provides a clinically valuable non-invasive method for assessing growth and development disorders.
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