Evidence map›Paper›PMID 40999537›Full record

Observational studyCritical care (London, England)2025

Oropharyngeal ultrafast ultrasound measurements in mechanically ventilated critically ill patients do not identify post-extubation stridor.

Margaux Machefert, Guillaume Prieur, Carlos Díaz López, Claire Dubois, Guillaume Schnell, Elise Artaud-Macari, Bouchra Lamia, Yann Combret, Clément Medrinal

2 registry-linked trialsAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05611437 unknown statusnot on this map

Ultrafast Ultrasonographic Oro-laryngeal Measurement in Critically Ill Patients During Weaning From Mechanical Ventilation

TypeobservationalSponsorGroupe Hospitalier du HavreRan2022 to 2024Enrolled150ConditionsLaryngeal EdemaArmsUltrafast ultrasonography
NCT07523828 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Relationship Between Assessment of Laryngeal Edema in Intensive Care Patients Using Cuff Leak Test and Ultrasound-Guided Laryngeal Air Column Width Difference and Weaning Success

Typeobservational_patient_registrySponsorFatih Sultan Mehmet Training and Research HospitalRan2026 to 2026Enrolled100ConditionsLaryngeal Edema
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Margaux MachefertPhysiotherapy Department, Le Havre Hospital, 76600, Le Havre, France. margaux.machefert@ch-havre.fr.
Guillaume PrieurPhysiotherapy Department, Le Havre Hospital, 76600, Le Havre, France.
Carlos Díaz LópezPhysiotherapy Department, Forcilles Hospital, 77150, Férolles-Attilly, France.
Claire DuboisPhysiotherapy Department, Le Havre Hospital, 76600, Le Havre, France.
Guillaume SchnellIntensive Care Unit, Le Havre Hospital, 76600, Le Havre, France.
Elise Artaud-MacariGRHVN UR 3830, Rouen Normandie University, 76000, Rouen, France.
Bouchra LamiaGRHVN UR 3830, Rouen Normandie University, 76000, Rouen, France.
Yann CombretPhysiotherapy Department, Le Havre Hospital, 76600, Le Havre, France.
Clément MedrinalPhysiotherapy Department, Le Havre Hospital, 76600, Le Havre, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-extubation stridor is a common complication of endotracheal intubation in ICU. This study aimed to assess whether a series of pre-extubation upper airway ultrasound measurements using shear wave elastography (SWE) could help in detecting post-extubation stridor.

methodsA prospective observational study (NCT05611437) was conducted between 2022 and 2024, which consecutively included 150 adults ICU patients intubated for more than 24 h, without prior surgical or neurological upper airway disease nor swallowing disorders. SWE measurements were performed in the 24 h before extubation. The occurrence of post-extubation stridor, dysphonia and swallowing disorders were assessed within 72 h.

results125 participants were included in the final analysis. A total of 2,625 ultrasound images were obtained, with 81% deemed interpretable. Post-extubation stridor occurred in 9% of patients and was independently associated with sepsis at admission (OR 8.98; 95%CI 1.3-62.1). No differences were observed between upper airway ultrasound in patients with or without stridor. Stridor was associated with higher rates of dysphonia (82% vs. 23%), swallowing disorders (36% vs. 11%), and extubation failure (46% vs. 10%). Swallowing disorders were independently associated with the duration of mechanical ventilation (OR 1.10; 95% CI 1.04-1.17). Dysphonia was associated with female sex (OR 3.23; 95%CI 1.24-8.37), sternothyroid muscle stiffness (OR 1.11; 95%CI 1.04-1.18), and days of mechanical ventilation (OR 1.09; 95%CI 1.02-1.15).

conclusionOropharyngeal SWE is feasible in critically ill patients before extubation, but was not predictive of post-extubation stridor. Further studies are needed to explore its role in predicting post-extubation upper airway complications.

Indexed as

Airway ExtubationOropharynxRespiration, ArtificialRespiratory SoundsAdultAgedCritical IllnessFemaleHumansIntensive Care UnitsIntubation, IntratrachealMaleMiddle AgedProspective StudiesUltrasonographyPost-extubation stridorShear wave elastographyUltrasonography

Identifiers

PMID40999537
PMCPMC12465404

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.