Evidence map›Paper›PMID 40999525›Full record

ArticleVeterinary research2025

Cav1.2 facilitates the binding and internalisation of porcine epidemic diarrhoea virus.

Xinxin Wang, Guilan Guo, Shutong He, Kaili Wang, Jianing Chen, Guijie Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xinxin Wang *Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.
Guilan Guo *Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.
Shutong HeKey Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.
Kaili WangKey Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.
Jianing ChenState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou, China.
Guijie GuoKey Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou, China. guoguijie@fafu.edu.cn.ORCID http://orcid.org/0000-0002-9031-1915

Funding

Natural Science Foundation of Fujian Province 2024J01388
6 · The paper itself

Abstract

Porcine epidemic diarrhoea virus (PEDV) has caused substantial economic losses to the global swine industry. The PEDV spike (S) protein mediates viral entry by interacting with host receptors. However, the molecular mechanisms underlying PEDV entry remain incompletely understood. In this study, we identified the L-type calcium channel Cav1.2 as a critical host factor for PEDV entry. Depletion of Cav1.2 significantly suppressed PEDV replication. Additionally, treatment with the FDA-approved Cav1.2 blocker diltiazem inhibited PEDV replication and disrupted early infection events. Mechanistically, we found that Cav1.2 interacts with the PEDV S1 subunit. Both Cav1.2 knockdown and diltiazem treatment substantially reduced the binding and internalisation of PEDV. These findings reveal that Cav1.2 is a key host factor for PEDV binding and internalisation via interaction with the viral S protein, and suggest that Cav1.2 may serve as a promising target for antiviral drug development against PEDV.

Indexed as

Calcium Channels, L-TypeCoronavirus InfectionsPorcine epidemic diarrhea virusSwine DiseasesVirus InternalizationAnimalsDiltiazemSpike Glycoprotein, CoronavirusSwineVirus ReplicationCalcium Channels, L-TypeDiltiazemL-type calcium channel alpha(1C)Spike Glycoprotein, CoronavirusCav1.2entry factorinternalisationPEDVviral binding

Identifiers

PMID40999525
PMCPMC12465407

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.