Evidence map›Paper›PMID 40999517›Full record

ArticleStem cell research & therapy2025

Fucoxanthin protects placenta-derived human mesenchymal stem cells against oxidative stress-induced apoptosis by modulating genes involved in DNA damage repair, ER stress response, p53-induced apoptosis.

Gunticha Suwanmanee, Pakpoom Kheolamai, Chairat Tantrawatpan, Daniel Grimes, Ioan Valentin Matei, Luminita Paraoan, Sirikul Manochantr

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gunticha SuwanmaneeDivision of Cell Biology, Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Pathumthani, 12120, Thailand.
Pakpoom KheolamaiDivision of Cell Biology, Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Pathumthani, 12120, Thailand.
Chairat TantrawatpanDivision of Cell Biology, Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Pathumthani, 12120, Thailand.
Daniel GrimesDepartment of Biology, Faculty of Arts and Sciences, Edge Hill University, BioSciences Building, St Helens Road, Ormskirk, L39 4QP, UK.
Ioan Valentin MateiDepartment of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Dalton Rm 5.35, Chester Street, Manchester, M1 5GD , UK.
Luminita ParaoanDepartment of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Dalton Rm 5.35, Chester Street, Manchester, M1 5GD , UK.
Sirikul ManochantrDivision of Cell Biology, Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Pathumthani, 12120, Thailand. msirikul@tu.ac.th.ORCID http://orcid.org/0000-0003-0565-3441

Funding

Center of Excellence in Stem Cell Research and Innovation at Thammasat University. Center of Excellence in Stem Cell Research and Innovation at Thammasat University.Faculty of Medicine, Thammasat University Faculty of Medicine, Thammasat UniversityRoyal Golden Jubilee (RGJ) Ph.D. program, National Research Council of Thailand (NRCT) and the Thailand Research Fund (TRF) NRCT5-RGJ63008-098Thailand Science Research and Innovation Fundamental Fund for the fiscal year 2024, Thammasat University TUFF 52/2567
6 · The paper itself

Abstract

Human mesenchymal stem cells (hMSCs) hold significant promise in regenerative medicine due to their ability to reduce inflammation and promote tissue repair. However, their therapeutic potential is often compromised by their high susceptibility to apoptosis under oxidative stress, prevalent in the microenvironment of the target tissues. Our previous study showed that fucoxanthin, a carotenoid derived from brown algae, can improve the viability of placenta-derived mesenchymal stem cells (PL-MSCs) by reducing intracellular ROS levels through the activation of the PI3K/Akt/Nrf-2 signaling pathway. In this study, we further investigate the mechanisms underlying the protective effect of fucoxanthin against oxidative stress-induced apoptosis in PL-MSCs, using an in vitro model. PL-MSCs were cultured with 750 µM H

Indexed as

ApoptosisDNA RepairEndoplasmic Reticulum StressMesenchymal Stem CellsOxidative StressPlacentaTumor Suppressor Protein p53XanthophyllsCells, CulturedDNA DamageFemaleHumansHydrogen PeroxidePregnancySignal TransductionfucoxanthinHydrogen PeroxideTP53 protein, humanTumor Suppressor Protein p53XanthophyllsApoptosisBiomarkersFucoxanthinMesenchymal stem cellsOxidative stressPlacenta

Identifiers

PMID40999517
PMCPMC12465192

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.