Evidence map›Paper›PMID 40999498›Full record

ArticleCritical care (London, England)2025

Temporal dimensions of oxygen saturation exposure and clinical outcomes in critically ill patients: a retrospective multi-database cohort study.

Xiao-Yan Ding, Hai-Ping Xu, Jing-Ru Zhang, Han Chen

Abstract read
In one paragraph

Article in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiao-Yan Ding *Cardiovascular Intensive Care Unit, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Dongjie 134, Gulou District, Fuzhou, Fujian, China.
Hai-Ping Xu *School of Computer and Big Data, Minjiang University, Fuzhou, China.
Jing-Ru ZhangThe School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Han ChenCardiovascular Intensive Care Unit, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Dongjie 134, Gulou District, Fuzhou, Fujian, China. baojr2@163.com.

Funding

Fujian Provincial Department of Finance Project {2024}881Fuzhou Science and Technology Project 2024-S-003Joint Funds for the Innovation of Science and Technology, Fujian Province 2024Y9005Natural Science Foundation of Fujian Province 2023J05250Startup Fund for scientific research, Fujian Medical University 2021QH1290
6 · The paper itself

Abstract

objectivesMost studies on SpO

methodsIn this retrospective cohort study, 121,758 critically ill patients were analyzed. The patient data were obtained from three databases: SICdb (n = 11,324) for continuous exposure analysis using heatmaps, MIMIC-IV (n = 50,110) for cumulative exposure analysis, and eICU (n = 60,324) for validation. We examined the relationships between SpO

resultsBoth analytical approaches revealed a U-shaped relationship between SpO

conclusionsOur study confirms a U-shaped relationship between SpO

Indexed as

Critical IllnessOxygenOxygen SaturationAdultAgedCohort StudiesDatabases, FactualFemaleHumansIntensive Care UnitsMaleMiddle AgedProportional Hazards ModelsRetrospective StudiesTime FactorsOxygenContinuous exposureCumulative exposureOptimal SpO2 rangeSpO2 exposure

Identifiers

PMID40999498
PMCPMC12465492

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.