ArticleGenome biology2025
Determinants of de novo mutations in extended pedigrees of 43 dog breeds.
Article in Genome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Review
- Integrative MRI and Genomics Analyses PrioritizeAnimals : an open access journal from MDPI · 2026Article
- Image feature embedding with a deep learning framework improves genome-wide association studies on dog endophenotypes.Science advances · 2026Article
- Dislodging the drift barrier: Why do mutation rates vary?Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A phylogenetic estimate of canine retrotransposition rates based on genome assembly comparisons.Mobile DNA · 2026Article
- An Assessment of the Population Dynamics and Evolutionary History of the Dingo.Ecology and evolution · 2026Article
- Article
- A phylogenetic estimate of canine retrotransposition rates based on genome assembly comparisons.bioRxiv : the preprint server for biology · 2025Article
- Determinants of de novo mutations in extended pedigrees of 43 dog breeds.Genome biology · 2025Article
- Rate of de novo mutations in the three-spined stickleback.Heredity · 2025Article
- Population size interacts with reproductive longevity to shape the germline mutation rate.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- VDGE: a data repository of variation database for gene-edited animals across multiple species.Nucleic acids research · 2025Article
- Dog10K: an integrated Dog10K database summarizing canine multi-omics.Nucleic acids research · 2025Article
- Population size interacts with reproductive longevity to shape the germline mutation rate.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
14 authors.
Funding
Abstract
backgroundUnderstanding the determinants of de novo mutation is critical for elucidating evolutionary processes and genetic disease susceptibility. But the interplay between life history, genomic architecture, and recombination remains poorly understood in non-model species. Domestic dogs, lacking the recombination regulator PRDM9 and subject to intense artificial selection, offer a unique system for dissecting factors that jointly influence mutation accumulation. Here, we leverage large-scale trio sequencing to unravel the determinants of de novo mutations across diverse dog breeds.
resultsBy analyzing 390 trios from 43 breeds, we estimate a germline mutation rate of 4.89 × 10
conclusionsThe unique mutational landscape in canids is determined by paternal age, body size, and CpG Islands recombination. Despite extensive breeding, germline mutation rates in dogs remain stable across breeds. The elevated mutation rate in CpG Islands due to recombination in the absence of PRDM9 underscores a distinct evolutionary mechanism in canids. These findings enhance our understanding of mutation dynamics, with implications for canine genetic diversity, disease susceptibility, and broader genomic studies in species lacking PRDM9.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.