Evidence map›Paper›PMID 40999460›Full record

ReviewEuropean journal of medical research2025

The dual roles of T cells and keratinocytes in seborrheic dermatitis: a narrative review.

Yangfan Xu, Xiaoliang Tong

Abstract readReview
In one paragraph

Review in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yangfan XuDepartment of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, People's Republic of China.
Xiaoliang TongDepartment of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, People's Republic of China. 209300440@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seborrheic dermatitis (SD) is a recurrent inflammatory skin disease primarily affects sebaceous gland-rich areas, particularly the scalp. Its characteristic clinical manifestations including dandruff, greasy crusting, and pruritus. These recurrent symptoms frequently impose significant psychological distress on patients. SD is classically associated with sebum secretion, Malassezia colonization, and individual susceptibility, whereas the critical roles of keratinocyte barrier dysfunction and T cell-mediated inflammation also constitute components in disease progression. In this review, we elucidate the mechanistic interplay between keratinocytes and T cells in SD development, proposing that their functional imbalance serves as a key driver of pathogenesis. We also systematically evaluate relevant therapies targeting keratinocytes and T cells, aiming to offer novel insights into SD pathophysiology and treatment.

Indexed as

Dermatitis, SeborrheicKeratinocytesT-LymphocytesHumansEtiologyInflammationKeratinocyteSeborrheic dermatitisT cell

Identifiers

PMID40999460
PMCPMC12465512

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.