Evidence map›Paper›PMID 40999459›Full record

SynthesisJournal of translational medicine2025

Comparative analysis of burden of topmost disorders requiring rehabilitation services: a systematic review and meta-analysis.

Echezona Nelson Dominic Ekechukwu, Olive Udunma Chijioke, Dorcas Tamilore Rotimi, Rajinder K Dhamija, Tochukwu Bright Ilechukwu, Paul Olowoyo, Amala Blessing Ojeh, Wuwei Feng, Solomon Chidubem Benjamin, Olumide Olasunkanmi Dada and 3 more

Abstract readSystematic ReviewMeta-AnalysisComparative Study
In one paragraph

Synthesis in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Echezona Nelson Dominic Ekechukwu *Department of Medical Rehabilitation, Faculty of Health Sciences and Technology, College of Medicine, University of Nigeria, Enugu, Nigeria.ORCID 0000-0002-0494-2869
Olive Udunma Chijioke *Department of Health Administration and Management, Faculty of Health Sciences and Technology, College of Medicine, University of Nigeria, Enugu, Nigeria.
Dorcas Tamilore RotimiDepartment of Medical Rehabilitation, Faculty of Health Sciences and Technology, College of Medicine, University of Nigeria, Enugu, Nigeria.
Rajinder K DhamijaInstitute of Human Behavior and Allied Sciences, New Delhi, India.ORCID 0000-0001-6042-7469
Tochukwu Bright IlechukwuDepartment of Medical Rehabilitation, Faculty of Health Sciences and Technology, College of Medicine, University of Nigeria, Enugu, Nigeria.
Paul OlowoyoDepartment of Medicine, Afe Babalola University, Ado-Ekiti, Nigeria.ORCID 0000-0002-0802-8505
Amala Blessing OjehDepartment of Medical Rehabilitation, Faculty of Health Sciences and Technology, College of Medicine, University of Nigeria, Enugu, Nigeria.
Wuwei FengDepartment of Neurology, Duke University School of Medicine, Durham, USA.ORCID 0000-0001-6230-4905
Solomon Chidubem BenjaminDepartment of Medical Rehabilitation, Faculty of Health Sciences and Technology, College of Medicine, University of Nigeria, Enugu, Nigeria.
Olumide Olasunkanmi DadaDepartment of Physiotherapy, Faculty of Clinical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.ORCID 0000-0002-1511-6757
Blessing Chiagozikam AtueyiDepartment of Neurology, Duke University School of Medicine, Durham, USA.
Thomas PlatzBDH-Klinik Greifswald, Institute for Neurorehabilitation and Evidence-Based Practice, University of Greifswald, Greifswald, Germany.ORCID 0000-0003-2629-9744
Mayowa Ojo OwolabiDepartment of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria. mayowaowolabi@yahoo.com.ORCID 0000-0003-1146-3070

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRehabilitation is an essential health service that should be available for all with health conditions affecting functioning in daily life. Initiatives for equitable distribution of scarce and limited rehabilitation resources are frequently guided by burden of diseases measures. Most studies on burden of diseases have laid greater emphasis on disability adjusted life years (DALYs) and rarely compared these burdens among conditions. This present study aims to systematically review and compare the burden of the top 10 GBD ranking of disorders.

methodThis review was pre-registered with PROSPERO (CRD42022316091). PubMed and Google Scholar were systematically searched as well as a manual search of grey literatures from 01/01/1990 to 29/02/2022. The results of this review were reported based on PRISMA guideline. Meta-analysis results were presented using forest plots and summary tables.

resultsA total of 11,367 studies were obtained from the searches, while the findings of 55 studies (17,753,434 participants) were reviewed. Majority of the studies were conducted in high-income-countries (56.1%) though, all the studies on neonatal disorders (100.0%) and congenital birth disorders (100.0%) came from the low-and-middle-income-countries. Neonatal disorders, stroke and ischaemic heart disease (IHD) topped the rank of disease burden. Overall, the burden of neurological disorders and their associated risk factors (aRFs), in terms of disease prevalence, were evaluated to be 36.75% while their mortality rate was 29.90%. Neurological conditions and aRFs accounted for 61.83% of total economic burden.

conclusionNeonatal disorders, stroke and IHD are the three most burdensome disorders. There is therefore need for greater focus of rehabilitation attention and resources in the coming decades.

Indexed as

Cost of IllnessRehabilitationDisability-Adjusted Life YearsHumansPublication BiasBurden of diseasesComparative analysisRehabilitationSystematic review

Identifiers

PMID40999459
PMCPMC12462021

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.