ArticleLipids in health and disease2025
Blood omega-3 fatty acids and coronary artery stenosis: a postmortem study.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The role of omega-3 fatty acids in the atherosclerotic process remains unclear. Early studies demonstrated a profound anti-atherogenic effect of cod liver oil in a pig model, and autopsy reports from Alaska Natives consuming omega-3 rich diets have supported this hypothesis, but meta-analyses of omega-3 randomized trials have produced mixed results vis-à-vis cardiovascular disease. The present study was undertaken to examine the relationship between post-mortem blood omega-3 levels and maximal stenosis of the coronary arteries at autopsy. Blood was collected from the femoral artery of 112 sequential fatalities and analyzed for fatty acid composition. The erythrocyte EPA + DHA level (the omega-3 index) was found to have degraded compared to levels in 30 living controls, but the ratio of Arachidonic Acid (AA) to EPA was unaffected, thus it was used as a biomarker of omega-3 status. We found no association between the maximal coronary artery stenosis and the AA: EPA ratio. The omega-3 index estimated from the AA: EPA ratio in the cases was 2.1%, one of the lowest mean values for any population yet tested. Thus, the lack of association between omega-3 status and coronary atherosclerosis may be due to the very low omega-3 index in this cohort.
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