ReviewReproductive biology and endocrinology : RB&E2025
Role of hyaluronan in endometrial receptivity: key insights for implantation and reproductive success.
Review in Reproductive biology and endocrinology : RB&E, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hyaluronic acid for vaginal health and quality of life in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Pooled it
- Molecular Crosstalk Between Intrauterine hCG and Endometrial Receptivity: Signalling Pathways, Immune Modulation, and Translational Perspectives in IVF.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Infertility affects millions worldwide, and implantation failure remains a critical barrier in assisted reproduction. Endometrial receptivity, a fundamental prerequisite for successful implantation, involves precise regulation of extracellular matrix components, with hyaluronan (HA) being particularly significant due to its structural and signaling roles. This study evaluated the expression of genes involved in HA metabolism and regulation across different phases of the menstrual cycle, particularly emphasizing their role during the window of implantation in normal fertility and repeated in vitro fertilization failures. Analysis of publicly available transcriptomic datasets revealed distinct expression patterns of HA synthases (HAS2, HAS3), HA-degrading enzymes (HYAL2, CEMIP, CEMIP2), and HA receptors (CD44, RHAMM, layilin) in endometrium that dynamically change toward the receptive state. Notably, HAS enzymes and HA receptors were upregulated during the mid-secretory phase, whereas classical HA-degrading enzymes showed complex regulation, suggesting a balance between HA synthesis and degradation necessary for optimal endometrial function. In patients with repeated IVF failure, there was significant downregulation of key HA-related genes (HAS2, HAS3, CEMIP, CD44, versican, syndecans), implicating impaired HA metabolism in implantation failure. The results underscore the role of HA metabolism and HA receptors in establishing a receptive endometrial environment, highlighting HA and its associated pathways as potential therapeutic targets to enhance reproductive success rates. Further research is necessary to unravel the detailed molecular mechanisms of HA-mediated regulation and its translational implications for assisted reproduction technologies.
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Registered trials
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