SynthesisBMC surgery2025
Radiofrequency rhizotomy for multiple sclerosis-related trigeminal neuralgia: a systematic review and meta-analysis.
Synthesis in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Neurovascular Compression Syndromes of Cranial Nerves: A Multidisciplinary Guide to Management.Brain sciences · 2026Review
- Chronic Pain in Multiple Sclerosis: Mechanisms, Clinical Characteristics and Treatment Strategies.International journal of molecular sciences · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRadiofrequency rhizotomy (RFR) is one of the primary therapeutic options for managing patients suffering from multiple sclerosis-related trigeminal neuralgia (MS-TN). Given the increasing use of RFR for MS-TN and the absence of consensus on its efficacy, we aimed to assess the clinical application of RFR in this patient population.
methodsOn April 7, 2025, we conducted a systematic literature search. Studies that evaluated the pain-related outcomes of RFR in MS-TN patients were included.
resultsFifteen studies involving 278 MS-TN patients who received RFR were included. The meta-analysis revealed a pooled pain-free rate and adequate pain-relief rate of 78% (95% CI: 58%-93%) and 96% (95% CI: 89%-100%) at the initial follow-up. In addition, the meta-analysis demonstrated a pooled pain-free rate and adequate pain-relief rate of 64% (95% CI: 25%-95%) and 86% (95% CI: 63%-99%), respectively, at the last follow-up. The pooled complication rate in our study was 9% (95% CI: 1%-22%).
conclusionsRFR is associated with substantial immediate pain relief rates, reasonable complication rates, and favorable long-term pain-related outcomes. However, the long-term outcomes show considerable variability and should be interpreted cautiously. RFR can be considered one of the main therapeutic options for patients suffering from MS-TN, where the pain has limited their daily performance.
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