Evidence map›Paper›PMID 40999318›Full record

ArticleBMC pregnancy and childbirth2025

The efficacy of emergency cervical cerclage in singleton pregnancies at 26-27

Qiumin Zhu, Liping Qiu, Min Lv, Yining Zhao, Juan Wei, Mengmeng Yang, Hongmei Zhou, Baihui Zhao, Qiong Luo

Abstract readMulticenter Study
In one paragraph

Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qiumin Zhu *Department of Obstetrics, Quzhou Maternal and Child Health Care Hospital, Quzhou, Zhejiang, 324000, China.
Liping Qiu *Department of Obstetrics, Huzhou Maternity and Child Health Care Hospital, Huzhou, Zhejiang, 313000, China.
Min Lv *Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China.
Yining ZhaoDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China.
Juan WeiDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China.
Mengmeng YangDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China.
Hongmei ZhouDepartment of Obstetrics, Quzhou Maternal and Child Health Care Hospital, Quzhou, Zhejiang, 324000, China.
Baihui ZhaoDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China. zhaobh@zju.edu.cn.
Qiong LuoDepartment of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China. Luoq@zju.edu.cn.

Funding

National Key Research and Development Program of China 2022YFC2704600, 2022YFC2704601
6 · The paper itself

Abstract

backgroundPresently, cervical cerclage is regarded as a valid method to treat cervical insufficiency, which could reduce late miscarriage and spontaneous preterm birth (sPTB). Nonetheless, the safety and effectiveness of emergency cervical cerclage (ECC) as a high-risk surgery still remains debatable when the cervix has dilated or the membranes protrude into the vagina during pregnancy at 26-27

objectiveTo estimate maternal and perinatal outcomes of ECC in singleton pregnancy at 26-27

methodsIn this multicenter retrospective cohort study, the study group comprised all singleton pregnancy without signs of labor or chorioamnionitis at 26-27

resultsFifty-four women underwent ECC (ECC group), while 114 were treated with expectant treatment (Control group). Demographic characteristics were similar in two groups. However, the pregnancy latency was significantly longer (66.21 vs 33.53 days, p < 0.001) and the GA at delivery was significantly higher (36 vs 30.45 weeks, p < 0.001) in ECC group compared with control group. The rates of sPTB at different GAs, as well as neonatal related indicators (live births only) also displayed noticeable difference between two groups (p < 0.001). For subgroup analysis, either cervical dilation ≥ 3cm or < 3 cm, ECC group both delineated later GA at delivery and better neonatal outcomes verse Control group (p < 0.05). After adjusting for confounding factors which were represented by a directed acyclic graph (DAG), there were significant differences in the GA at delivery (beta, 5.195; 95% CI, 3.818 - 8.572; p < 0.001), pregnancy latency (beta, 34.160; 95% CI, 17.799 - 50.522; p < 0.001), the rates of sPTB at < 28, < 30, < 32, < 34, < 36 weeks were all significantly lower than those in the control group (all p < 0.001), and neonatal birthweight was significantly increased (beta, 1007.427; 95%CI, 715.300 - 1299.554; p < 0.001), and the rates of 5-min Apgar > 7 was significantly higher in ECC group when compared with the control group, further indicated that ECC in singleton pregnancies with cervical dilation 0.5-4 cm in 26-27

conclusionIn singleton pregnant women with cervical dilation 0.5-4 cm at 26-27

Indexed as

Cerclage, CervicalPremature BirthUterine Cervical IncompetenceAdultChinaFemaleGestational AgeHumansInfant, NewbornPregnancyPregnancy OutcomeRetrospective StudiesCervical dilationEmergency cervical cerclageMaternal and perinatal outcomesPreterm birthSingle pregnancy

Identifiers

PMID40999318
PMCPMC12465691

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.