Evidence map›Paper›PMID 40999305›Full record

ArticleScience China. Life sciences2026

Gut microbial genetic variations are associated with exploratory behavior via SNV-driven metabolic regulation in a sheep model.

Shuai Yang, Beining Ma, Mengke Gao, Jiahua Wu, Dale Pilling, Lin Zhu, Xiuchao Wang, Quanbin Dong, Yifeng Wang, Kelsey Pool and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shuai Yang *Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, Nanjing, 210029, China.
Beining Ma *Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, Nanjing, 210029, China.
Mengke Gao *Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, Nanjing, 210029, China.
Jiahua Wu *Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, Nanjing, 210029, China.
Dale PillingSchool of Human Sciences, The University of Western Australia, Crawley, 6009, Australia.
Lin ZhuDepartment of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, Nanjing, 210029, China.
Xiuchao WangDepartment of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, Nanjing, 210029, China.
Quanbin DongDepartment of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, Nanjing, 210029, China.
Yifeng WangDepartment of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, Nanjing, 210029, China.
Kelsey PoolSchool of Agriculture and Environment, The University of Western Australia, Crawley, 6009, Australia.
Shane MaloneySchool of Human Sciences, The University of Western Australia, Crawley, 6009, Australia.
Peng LiDepartment of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, Nanjing, 210029, China. lipeng198610@163.com.
Dominique BlacheSchool of Agriculture and Environment, The University of Western Australia, Crawley, 6009, Australia. dominique.blache@uwa.edu.au.
Luoyang DingSchool of Agriculture and Environment, The University of Western Australia, Crawley, 6009, Australia. luoyang.ding@uwa.edu.au.
Lianmin ChenDepartment of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, Nanjing, 210029, China. lianminchen@njmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Host neurocognitive functions are influenced by the gut microbiome, but the role of microbial genetic variation in shaping host neural behavior remains unexplored. Here, we profiled multi-omics data and neurobehavioral phenotypes in a model of 200 Merino sheep. Genomic reconstruction of deeply sequenced fecal and ruminal samples generated 5,253 species-level metagenomic-assembled genomes, of which 3,548 were identified as novel species when compared with existing databases of sheep. Association between strain-level genetic dissimilarities and host neurobehavioral traits showed that phylogenetic differences in 85% of species were associated with exploratory behavior (FDR<0.05). We further associated 146 million microbial single nucleotide variations (SNVs) with 953 plasma metabolites and identified 34 study-wide significant associations (P<2.9×10

Indexed as

Gastrointestinal MicrobiomeGenetic VariationPolymorphism, Single NucleotideAnimalsBehavior, AnimalFecesMultiomicsPhylogenySheepgut microbiomemetabolomicsmicrobial genetic variationneurocognitionsingle nucleotide variation

Identifiers

PMID40999305

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.