ArticleBreast cancer (Tokyo, Japan)2026
Pathological homogeneity and utility in the genetic diagnosis of paired mirror samples from breast cancer 10G-vacuum-assisted biopsies using a novel longitudinal dividing device.
Article in Breast cancer (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe growing need for immunohistochemical and genetic testing often results in shortage of breast cancer vacuum-assisted biopsy (VAB) samples. Their value has become increasingly important with improvements in neoadjuvant chemotherapy outcomes. To enhance diagnostic utility, the longitudinal division of a single VAB sample can provide matched "mirror samples." We adapted a prostate biopsy tissue divider for use with 10G-VAB breast cancer specimens and evaluated its feasibility for pathological and molecular analyses.
methodsA total of 100 10G-VAB specimens from 32 patients were longitudinally bisected using the dividing tool. The pathological concordance between the paired mirror samples was assessed by histological examination. Their suitability for DNA and mRNA analyses was also evaluated by next-generation gene panel sequencing and microarray-based gene expression profiling.
resultsOf the 72 samples confirmed to contain malignant tissue, 70 (97.2%) exhibited high pathological concordance between the mirror pairs. The remaining two samples (2.8%), derived from the tumor margins, exhibited discordant histological findings. Moreover, gene panel testing (n = 8) and comprehensive gene expression profiling using microarray (n = 8) were successfully performed on all of the mirror samples (n = 16).
conclusionThe longitudinal division of breast cancer VAB tissue using a specialized dividing device results in anatomically matched mirror samples with high pathological fidelity. These specimens are suitable for advanced molecular diagnostics, thus providing a valuable tool for clinical practice and translational studies.
Indexed as
Identifiers
40999271What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.