Evidence map›Paper›PMID 40999259›Full record

ArticleJournal of medical ultrasonics (2001)2026

Dynamic contrast-enhanced ultrasound with quantitative analysis optimizes LI-RADS for hepatocellular carcinoma diagnosis: a multicenter study.

Ya-Qin Zhang, Xi Wang, Lin-Na Liu, Xin-Yuan Hu, Qing Lu, Bo-Yang Zhou, Han-Sheng Xia, Hong Han, Hui-Xiong Xu, Chong-Ke Zhao

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of medical ultrasonics (2001), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Ya-Qin Zhang *Department of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University, Shanghai, China.
Xi Wang *Department of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University, Shanghai, China.
Lin-Na Liu *Department of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University, Shanghai, China.
Xin-Yuan HuDepartment of Ultrasound, Shanghai Geriatric Medical Center, Shanghai, China.
Qing LuDepartment of Ultrasound, Zhongshan Hospital (Xiamen Branch), Fudan University, Xiamen, China.
Bo-Yang ZhouDepartment of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University, Shanghai, China.
Han-Sheng XiaDepartment of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University, Shanghai, China.
Hong HanDepartment of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University, Shanghai, China.
Hui-Xiong XuDepartment of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University, Shanghai, China. xuhuixiong@126.com.
Chong-Ke ZhaoDepartment of Ultrasound, Zhongshan Hospital, Institute of Ultrasound in Medicine and Engineering, Fudan University, Shanghai, China. zhaochongke123@163.com.

Funding

Horizontal Project of Zhongshan Hospital of Fudan University H2024-077National Natural Science Foundation of China 82202174Scientific Research and Development Fund of Zhongshan Hospital of Fudan University 2022ZSQD07Shanghai Municipal Health Commission 2019LJ21Shanghai Municipal Health Commission SHSLCZDZK03502Shanghai Science and Technology Innovation Action Plan 21Y11911200The Science and Technology Commission of Shanghai Municipality 18441905500The Science and Technology Commission of Shanghai Municipality 19DZ2251100
6 · The paper itself

Abstract

purposeTo investigate the value of dynamic contrast-enhanced ultrasound (DCE-US) analysis using the Liver Imaging Reporting and Data System (LI-RADS) to improve the diagnosis of hepatocellular carcinoma (HCC).

methodsThis multicenter study retrospectively enrolled consecutive high-risk patients for HCC who underwent contrast-enhanced ultrasound (CEUS) between December 2022 and June 2023. Quantitative CEUS analysis was performed using VueBox

results269 patients (median age, 61 years [interquartile range, 52-69]; 206 men, 63 women) with 269 focal liver lesions (FLLs) (median size, 40 mm [interquartile range, 25-62 mm]) were included. Among the 269 FLLs, 227 were HCC, 31 non-HCC malignancies, and 11 benign lesions. DCE-US analysis showed HCC had higher rise time (RT) and fall time (FT) at the lesion margin than non-HCC malignancies (both P < 0.05) but lower RT and FT than benign lesions (both P < 0.05). RT at the lesion margin (range 17.48 s-21.16 s) serves as an auxiliary indicator for HCC diagnosis. Compared to CEUS LI-RADS, the revised LR-5 improved sensitivity (61.7 vs. 52.8%, P < 0.001) without a significant decrease in specificity (76.2 vs. 83.3%, P = 0.25) for diagnosing HCC.

conclusionDCE-US quantitative analysis improved the sensitivity for HCC diagnosis without affecting specificity, thereby optimizing the diagnostic performance of CEUS LI-RADS.

Indexed as

Carcinoma, HepatocellularContrast MediaImage EnhancementLiver NeoplasmsAgedFemaleHumansLiverMaleMiddle AgedRetrospective StudiesSensitivity and SpecificityUltrasonographyContrast MediaDynamic contrast-enhanced ultrasoundHepatocellular carcinomaLiver Imaging Reporting and Data SystemQuantitative analysis

Identifiers

PMID40999259

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.