ArticleNature cardiovascular research2025
Assessing cerebral microvascular volumetric with high-resolution 4D cerebral blood volume MRI at 7 T.
Article in Nature cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Assessing molecular, cellular and transcriptomic bases of laminar perfusion and cytoarchitecture coupling in the human cortex.Nature communications · 2026Article
- Multimodal Free-Water Imaging Links Cardiometabolic Risk to Periarterial Dysfunction and Amyloid Accumulation in Early Alzheimer's.Research square · 2026Article
- Cortical Microvascular Pulsatility in the Aging Mouse Brain and the Confounding Effects of Anesthesia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Assessing molecular, cellular and transcriptomic bases of laminar perfusion and cytoarchitecture coupling in the human cortex.bioRxiv : the preprint server for biology · 2025Article
- The pulsing brain: state of the art and an interdisciplinary perspective.Interface focus · 2025Review
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7 authors.
Funding
Abstract
Arterial pulsation is crucial for promoting neurofluid circulation. Most previous studies quantified pulsatility via blood velocity-based indices in large arteries. Here we propose an innovative method to quantify the microvascular volumetric pulsatility index (mvPI) across cortical layers and white matter (WM) using high-resolution four-dimensional (4D) vascular space occupancy (VASO) and arterial spin labeling (ASL) magnetic resonance imaging (MRI) at 7 T with simultaneous pulse recording. We assessed aging-related changes in mvPI in 11 young (28.4 ± 5.8 years) and 12 older (60.2 ± 6.8 years) participants and compared mvPI with large artery pulsatility assessed by 4D-flow MRI. mvPI peaked in the pial surface (0.18 ± 0.04). Deep WM mvPI was significantly higher in older participants (P = 0.006) than young ones. Deep WM mvPI correlated with large artery velocity PI (r = 0.56, P = 0.0099). We performed test-retest scans, non-parametric reliability test and simulations to demonstrate the reproducibility and accuracy of the method. In conclusion, our non-invasive method enables in vivo fine-grained measurement of mvPI, with implications for glymphatic function, aging and neurodegenerative diseases.
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