Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05697172 (Neuromodulation of Circuits Underlying Repetitive Negative and Self-Referential Thinking in Depression), which is not on this map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuromodulation of Circuits Underlying Repetitive Negative and Self-Referential Thinking in Depression: An Early Feasibility Study Employing Transcranial Focused Ultrasound
TypeinterventionalSponsorLaureate Institute for Brain Research, Inc.Ran2022 to 2024Enrolled30ConditionsMajor Depressive DisorderArmsLow-intensity focused ultrasound
The Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)P20GM121312 · NIGMS · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI MARTIN P. PAULUS · 2017 to 2026
$23.7M
A neurocomputational assay of gastrointestinal interoception in anorexia nervosaR01MH127225 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI KHALSA, SAHIB S., PAULUS, MARTIN P. · 2021 to 2025
$3.2M
Neurally targeted group intervention to reduce early childhood anxietyR33MH121641 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FITZGERALD, KATE DIMOND, MOSER, JASON SCOT · 2021 to 2023
$2.6M
Low intensity focused ultrasound: a new paradigm for depression and anxietyU01MH123427 · NIMH · OCEAN STATE RESEARCH INSTITUTE, INC. · PI PHILIP, NOAH STEPHEN · 2021 to 2024
$2.4M
Suicide Circuit Therapeutics: Engaging Novel Targets with Rapid and Individualized MRI-Guided Accelerated TMSR61MH132869 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI CAMPRODON, JOAN A · 2023 to 2024
$2.1M
Cognitive control targets for the treatment of obsessive compulsive disorder in young childrenR61MH129544 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FITZGERALD, KATE DIMOND, MARSH, RACHEL · 2023 to 2024
$1.8M
Parsing Mechanistic Relationships Between Circuits and Negative Valence System Behaviors in Treatment-Resistant Depression with Ultrasound NeuromodulationR01MH137331 · NIMH · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Salvador Martin Guinjoan · 2025 to 2026
$923k
Individualized Closed-Loop Neuromodulation Therapy for Alzheimer's DiseaseR21AG078692 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI CAMPRODON, JOAN A, DICKERSON, BRADFORD C · 2022 to 2023
$469k
Cortical hyperexcitability in FTD and ALS: Exploring physiological biomarkersR21AG081925 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI CAMPRODON, JOAN A, DICKERSON, BRADFORD C · 2024 to 2024
$459k
State-dependent modulation of interactions of theta and gamma rhythms in working memoryR21MH131878 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI CAMPRODON, JOAN A, ERYILMAZ, H HAMDI · 2023 to 2023
$459k
Dose-Dependent Functional Connectivity Effects of Low-Intensity Focused Ultrasound Applied to Deep White Matter Tracts in HumansR21MH138911 · NIMH · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Salvador Martin Guinjoan · 2025 to 2026
$411k
NIA NIH HHS R21 AG078692NIA NIH HHS R21 AG081925NIGMS NIH HHS P20 GM121312NIMH NIH HHS R01 MH127225NIMH NIH HHS R01 MH137331NIMH NIH HHS R21 MH131878NIMH NIH HHS R21 MH138911NIMH NIH HHS R33 MH121641NIMH NIH HHS R61 MH129544NIMH NIH HHS R61 MH132869NIMH NIH HHS U01 MH123427RRD VA I50 RX002864U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) P20GM121312U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH127225U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH137331U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21MH138911U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R33MH121641U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R61MH129544U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) U01MH123427
6 · The paper itself
Abstract
Current efforts to establish anatomically precise and causal deep brain circuit-symptom relationships to predict surgical responses require the insertion of intracranial electrodes. In the present study (ClinicalTrials.gov NCT05697172) we examined whether low-intensity focused ultrasound (LIFU; FDA Q220192) could modulate the white matter tracts in the anterior limb of the internal capsule (ALIC), a common surgical target for the treatment of refractory depression. We based our human study on the in vitro observation that ultrasound attenuates conduction in myelinated axons by operating mechanosensitive potassium channels in nodes of Ranvier. We employed a cross-over, randomized, sham-controlled, double-blind design to establish the ability of LIFU (80 s; 0.5 MHz; estimated peak tissue energy 2.26 Watt/cm
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Reversible modulation of a deep white matter surgical target for depression with low-intensity focused ultrasound. · full record | OpenQuestion