Evidence map›Paper›PMID 40999233›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2025

Concerted elevations of cortical and striatal glutamate and GABA in antipsychotic-free individuals at clinical high-risk for psychosis.

Ragy R Girgis, Camilo de la Fuente-Sandoval, Roberto Lewis-Fernández, Francisco Reyes-Madrigal, Melanie M Wall, Jialiang Hua, Xiangling Mao, Melanie Malacara, Lawrence S Kegeles, Dikoma C Shungu

Abstract readMulticenter Study
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ragy R Girgis *Department of Psychiatry and New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY, USA. Ragy.Girgis@nyspi.columbia.edu.ORCID http://orcid.org/0000-0001-5715-8982
Camilo de la Fuente-Sandoval *Laboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.ORCID http://orcid.org/0000-0003-0773-1642
Roberto Lewis-FernándezDepartment of Psychiatry and New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY, USA.
Francisco Reyes-MadrigalLaboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.ORCID http://orcid.org/0000-0003-0772-4119
Melanie M WallDepartment of Psychiatry and New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY, USA.
Jialiang HuaDepartment of Psychiatry and New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY, USA.
Xiangling MaoDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA.
Melanie MalacaraLaboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.
Lawrence S KegelesDepartment of Psychiatry and New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY, USA.
Dikoma C ShunguDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-9452-2245

Funding

Biomarkers of Conversion Risk and Treatment Response in Early-Stage SchizophreniaR01MH110270 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI GIRGIS, RAGY RAMSIS, KEGELES, LAWRENCE S · 2017 to 2021
$3.7M
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH110270
6 · The paper itself

Abstract

While the literature on glutamate and γ-aminobutyric acid (GABA) levels as measured by proton magnetic spectroscopy (

Indexed as

Corpus Striatumgamma-Aminobutyric AcidGlutamic AcidPrefrontal CortexPsychotic DisordersAdultFemaleHumansMaleProton Magnetic Resonance SpectroscopyYoung Adultgamma-Aminobutyric AcidGlutamic Acid

Identifiers

PMID40999233
PMCPMC12603105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.