Evidence map›Paper›PMID 40999198›Full record

ArticleInternational journal of obesity (2005)2026

The Physiology of the WEight-Reduced State (POWERS) study: environmental, psychological, and social determinants of health.

Sai Krupa Das, Giada Benasi, John M Jakicic, Wendy C King, Susan Z Yanovski, Stephanie S Kelley, Laurel E S Mayer, Kathryn J Whyte, Michael R Lowe, Susan B Roberts and 2 more

Abstract read
In one paragraph

Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sai Krupa Das *Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA. sai.das@tufts.edu.ORCID 0000-0003-0788-0461
Giada BenasiDivision of General Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-1537-6655
John M JakicicDivision of Physical Activity and Weight Management, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.ORCID 0000-0001-6800-9368
Wendy C KingDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-0740-0029
Susan Z YanovskiRockville, MD, USA.
Stephanie S KelleyDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Laurel E S MayerDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Kathryn J WhyteDepartment of Pediatrics, Molecular Genetics, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Michael R LoweDepartment of Psychological and Brain Sciences, Drexel University, Philadelphia, PA, USA.
Susan B RobertsGeisel School of Medicine, Dartmouth College, Hanover, NH, USA.ORCID 0000-0003-1320-8460
Maren R Laughlin *Division of Diabetes, Endocrinology, & Metabolic Diseases, NIDDK, NIH, Bethesda, MD, USA.
POWERS Consortium

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DOUGLAS J EPSTEIN · 1986 to 2026
$48.3M
RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
TUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI SHALENDER BHASIN · 2008 to 2026
$23.9M
Predictors of Recidivism to Obesity in Weight-Reduced IndividualsUH3DK128302 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DYMPNA GALLAGHER, RUDOLPH L LEIBEL · 2022 to 2026
$7.0M
Predicting Weight Regain Following Weight Loss Using Physiological Measures of Appetite and Energy ExpenditureUH3DK128298 · NIDDK · DREXEL UNIVERSITY · PI KELLY C ALLISON, MATTHEW R HAYES · 2022 to 2026
$6.8M
The Physiology of the Weight Reduced State Data Coordinating CenterU24DK128125 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Steven H. Belle, Maria Mori Brooks · 2021 to 2026
$4.9M
OBESITY RESEARCH CENTER TRAINING PROGRAMT32DK007559 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI DYMPNA GALLAGHER · 1989 to 2026
$4.3M
Interpretable graphical models for large multi-modal COPD data (R01HL159805)R01HL159805 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENOS, PANAGIOTIS V, SPIRTES, PETER · 2021 to 2024
$2.0M
Support Mentoring of Early Career Clinical Researchers from Diverse BackgroundsK26DK138418 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DYMPNA GALLAGHER · 2023 to 2026
$483k
NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1 TR001878NHLBI NIH HHS R01 HL159805NIA NIH HHS P30 AG031679NIDDK NIH HHS K26 DK138418NIDDK NIH HHS P30 DK019525NIDDK NIH HHS P30 DK026687NIDDK NIH HHS T32 DK007559NIDDK NIH HHS U24 DK128125NIDDK NIH HHS UH3 DK128298NIDDK NIH HHS UH3 DK128302
6 · The paper itself

Abstract

Intentional weight loss is often followed by unintentional weight regain. The causes of weight regain are uncertain but may include a myriad of responses that result in increased hunger and decreased energy expenditure. An individual's psychological state and social and physical environments are also thought to influence weight regain in ways that can either support or derail weight loss maintenance. Funded by the National Institutes of Health, the Physiology of the WEight Reduced State (POWERS) study is a multi-center clinical trial aimed at describing the molecular, cellular, physiological, behavioral, environmental and psychosocial factors that may be associated with an individual's ability to maintain their new weight after weight loss. This report provides the rationale for and describes the environmental, psychological and social determinants of health measures used in the POWERS study.

Indexed as

ObesitySocial Determinants of HealthWeight LossClinical Trials as TopicEnergy MetabolismFemaleHumansMaleMulticenter Studies as TopicSocial EnvironmentUnited StatesWeight Gain

Identifiers

PMID40999198
PMCPMC12855017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.