Evidence map›Paper›PMID 40999190›Full record

ArticleArchives of pharmacal research2025

Germacrane and humulane sesquiterpenes from the roots and rhizomes of Valeriana officinalis var. latifolia and their anti-inflammatory and anti-influenza virus activities.

Jia-Jin Liu, Li-Zhong Wang, Yuan-Ting Duan, Rong-Tao Li, Dan Liu, Hong-Mei Li

Abstract read
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Article in Archives of pharmacal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jia-Jin Liu *Faculty of Life Science and Technology, Kunming University of Science and Technology, 727 Jingming South Road, Chenggong District, Kunming, 650500, Yunnan, People's Republic of China.
Li-Zhong Wang *Faculty of Life Science and Technology, Kunming University of Science and Technology, 727 Jingming South Road, Chenggong District, Kunming, 650500, Yunnan, People's Republic of China.
Yuan-Ting DuanFaculty of Life Science and Technology, Kunming University of Science and Technology, 727 Jingming South Road, Chenggong District, Kunming, 650500, Yunnan, People's Republic of China.
Rong-Tao LiFaculty of Life Science and Technology, Kunming University of Science and Technology, 727 Jingming South Road, Chenggong District, Kunming, 650500, Yunnan, People's Republic of China.
Dan LiuFaculty of Life Science and Technology, Kunming University of Science and Technology, 727 Jingming South Road, Chenggong District, Kunming, 650500, Yunnan, People's Republic of China. liudankm512@163.com.
Hong-Mei LiFaculty of Life Science and Technology, Kunming University of Science and Technology, 727 Jingming South Road, Chenggong District, Kunming, 650500, Yunnan, People's Republic of China. lihongmei0823@163.com.

Funding

Key R&D Program of Yunnan Province 202103AC10005Major Science and Technology Projects in Yunnan Province 202302AG050004National Natural Science Foundation of China 22207048National Natural Science Foundation of China 32060106National Natural Science Foundation of China 82204248
6 · The paper itself

Abstract

Twenty-seven sesquiterpenes, including twenty-one new germacrane-type ones (1-5, 8-16, and 19-25) and a new humulane-type one (27), were isolated from the roots and rhizomes of Valeriana officinalis var. latifolia. The structures and absolute configurations of the new compounds were elucidated using extensive spectroscopic techniques (1D and 2D NMR, and HRESIMS) and quantum chemical calculations. Structurally, compound 20 was a new germacrane-type norsesquiterpene, while compound 27 was a new humulane-type norsesquiterpene. In addition, compound 27 significantly inhibited the production of nitric oxide with an IC

Indexed as

Anti-Inflammatory AgentsAntiviral AgentsInfluenza A virusSesquiterpenesSesquiterpenes, GermacraneValerianAnimalsDose-Response Relationship, DrugLipopolysaccharidesMacrophagesMiceMolecular StructureNitric OxidePlant ExtractsPlant RootsRAW 264.7 CellsAnti-Inflammatory AgentsAntiviral AgentsLipopolysaccharidesNitric OxidePlant ExtractsSesquiterpenesSesquiterpenes, GermacraneAnti-inflammatoryAnti-influenza virusCaprifoliaceaeSesquiterpenesValeriana officinalis var. latifolia

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.