Evidence map›Paper›PMID 40999132›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Subthalamic deep brain stimulation does not impact on cardiovascular and sudomotor functions assessed by head-up tilt test and sudoscan.

Camilla Rocchi, Kristi Meksi, Rocco Cerroni, Elena Garasto, Francesco Bove, Carla Piano, Nicola Biagio Mercuri, Alessandro Stefani, Livia Brusa

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Camilla RocchiParkinson's Disease Center, Policlinico Tor Vergata, University of Rome "Tor Vergata", Rome, Italy.
Kristi MeksiParkinson's Disease Center, Policlinico Tor Vergata, University of Rome "Tor Vergata", Rome, Italy.
Rocco CerroniParkinson's Disease Center, Policlinico Tor Vergata, University of Rome "Tor Vergata", Rome, Italy.
Elena GarastoParkinson's Disease Center, Policlinico Tor Vergata, University of Rome "Tor Vergata", Rome, Italy.
Francesco BoveNeurology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo A. Gemelli 8, Rome, 00168, Italy. francesco.bove@policlinicogemelli.it.ORCID http://orcid.org/0000-0002-2959-6659
Carla PianoNeurology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo A. Gemelli 8, Rome, 00168, Italy.
Nicola Biagio MercuriParkinson's Disease Center, Policlinico Tor Vergata, University of Rome "Tor Vergata", Rome, Italy.
Alessandro StefaniParkinson's Disease Center, Policlinico Tor Vergata, University of Rome "Tor Vergata", Rome, Italy.
Livia BrusaNeurology Unit, S.Eugenio Hospital, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim of this study is to assess the effects of subthalamic deep brain stimulation (STN-DBS) on cardiovascular and sudomotor autonomic functions in Parkinson’s disease (PD) patients. Ten subjects with advanced PD and bilateral STN-DBS underwent head-up tilt test (HUTT) and electrochemical skin conductance (ESC) measured with Sudoscan, under three conditions: DBS ON and therapy OFF (DBS ON/Th OFF), 30 min after switching off the DBS (DBS OFF/Th OFF), and 30 min after switching on the DBS and administering melevodopa/carbidopa 100/25 mg (DBS ON/Th ON). A significant reduction in systolic blood pressure at the 10th minute of HUTT in the DBS ON/Th ON condition was detected, compared to the DBS OFF/Th OFF condition (p 0.036). No other significant differences were observed in heart rate (HR), blood pressure (BP) and electro-chemical skin conductance among the three conditions. STN-DBS does not influence cardiovascular and sudomotor autonomic regulation, however, it may exert a positive effect on cardiovascular reactivity by an indirect mechanism, as it decreases levodopa load.

Indexed as

Deep Brain StimulationGalvanic Skin ResponseParkinson DiseaseSubthalamic NucleusAgedAutonomic Nervous SystemBlood PressureFemaleHeart RateHumansMaleMiddle AgedTilt-Table TestAutonomic nervous systemCardiovascular reactivityDBS-STNParkinson's diseaseSudomotor assessment

Identifiers

PMID40999132

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.