Evidence map›Paper›PMID 40999075›Full record

ReviewCardiovascular and interventional radiology2026

Real-World Evidence: Better than Nothing or the Future? A Perspective on Clinical Evidence Generation in Interventional Oncology.

Nathalie C Kaufmann, Philippe L Pereira

Abstract readReview
In one paragraph

Review in Cardiovascular and interventional radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Clinical Trials in Interventional Oncology: A Field Growing Up Fast.Cardiovascular and interventional radiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nathalie C KaufmannCardiovascular and Interventional Radiological Society of Europe, Neutorgasse 9/6, 1010, Vienna, Austria. kaufmann@cirse.org.ORCID http://orcid.org/0000-0002-4823-6923
Philippe L PereiraCenter for Radiology, Minimally-Invasive Therapies and Nuclear Medicine, SLK Kliniken Heilbronn GmbH, University of Heidelberg, Am Gesundbrunnen 20-26, 74078, Heilbronn, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Randomised controlled trials (RCTs) have traditionally been regarded as the gold standard in evidence-based medicine, providing a high level of evidence. However, mounting complexities, ranging from ethical issues and logistical barriers to rapid technological evolutions, have sparked interest in alternative or complementary evidence-generation methods. Real-world evidence (RWE) from large, well-designed research projects is increasingly viewed as powerful tools. Although RWE is sometimes perceived as "less robust" compared to RCTs due to potential biases, recent advances in study design, data capture, and analytical frameworks have highlighted its potential for shaping clinical practice and informing regulatory decisions. This article discusses the benefits and challenges of RWE within interventional oncology and explores whether it is merely "better than nothing" or indeed represents a key pillar of the future of clinical research.

Indexed as

Evidence-Based MedicineMedical OncologyNeoplasmsRadiology, InterventionalHumansRandomized Controlled Trials as TopicResearch DesignInterventional radiologyObservational studiesOncologyRandomised controlled trialsReal-world dataReal-world evidenceRegistries

Identifiers

PMID40999075
PMCPMC13156222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.