Evidence map›Paper›PMID 40999064›Full record

ArticleEuropean journal of clinical nutrition2025

Dietary intake of folate, vitamin B6, vitamin B12, and riboflavin and the risk of incident dementia.

Rie Kishida, Kazumasa Yamagishi, Koutatsu Maruyama, Ai Ikeda, Mizuki Sata, Mari Tanaka, Chika Okada, Yasuhiko Kubota, Mina Hayama-Terada, Yuji Shimizu and 8 more

Abstract read
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Article in European journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Rie KishidaDepartment of Public Health Medicine, Institute of Medicine, and Health Services Research and Development Center, University of Tsukuba, Tsukuba, Japan.ORCID http://orcid.org/0009-0004-4961-7500
Kazumasa YamagishiDepartment of Public Health Medicine, Institute of Medicine, and Health Services Research and Development Center, University of Tsukuba, Tsukuba, Japan. yamagishi.kazumas.ge@u.tsukuba.ac.jp.ORCID http://orcid.org/0000-0003-3301-5519
Koutatsu MaruyamaDepartment of Bioscience, Graduate School of Agriculture, Ehime University, Matsuyama, Japan.ORCID http://orcid.org/0000-0002-7862-7693
Ai IkedaDepartment of Public Health, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Mizuki SataDepartment of Preventive Medicine and Public Health, Keio University, Tokyo, Japan.
Mari TanakaDepartment of Public Health, Faculty of Medicine, Kindai University, Osakasayama, Japan.
Chika OkadaDepartment of Public Health, Faculty of Medicine, Kindai University, Osakasayama, Japan.
Yasuhiko KubotaOsaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
Mina Hayama-TeradaYao City Public Health Center, Yao, Japan.
Yuji ShimizuEpidemiology Section, Division of Public Health, Osaka Institute of Public Health, Osaka, Japan.
Isao MurakiDepartment of Public Health Medicine, Institute of Medicine, and Health Services Research and Development Center, University of Tsukuba, Tsukuba, Japan.ORCID http://orcid.org/0000-0003-0058-7721
Mitsumasa UmesawaDepartment of Public Health Medicine, Institute of Medicine, and Health Services Research and Development Center, University of Tsukuba, Tsukuba, Japan.
Hironori ImanoDepartment of Public Health, Faculty of Medicine, Kindai University, Osakasayama, Japan.
Tomoko SankaiDepartment of Public Health Medicine, Institute of Medicine, and Health Services Research and Development Center, University of Tsukuba, Tsukuba, Japan.
Takeo OkadaOsaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
Akihiko KitamuraYao City Public Health Center, Yao, Japan.
Masahiko KiyamaOsaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.ORCID http://orcid.org/0000-0003-2635-6059
Hiroyasu IsoInstitute of Global Health Policy Research, Bureau of Global Health Cooperation, Japan Institute for Health Security, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesLow intake of B vitamins may increase dementia; However, epidemiological evidence, particularly for riboflavin (vitamin B₂), remains sparse. This study aimed to examine the association between dietary intakes of B vitamins (riboflavin, vitamin B

methodsAs part of the Circulatory Risk in Communities Study, a prospective study involving a community-based cohort of 4171 Japanese individuals aged 40-69 years was conducted. Dietary intakes of B vitamins were estimated through a single 24-h dietary recall method. Disabling dementia was defined by the daily living disability status related to dementia based on the long-term care insurance system of Japan. Hazard ratios of disabling dementia were estimated using area-stratified Cox proportional hazard models.

resultsOver a median follow-up of 15.4 years, 887 cases of disabling dementia were identified. Riboflavin intake was inversely associated with the risk of disabling dementia; the multivariable hazard ratio for the highest versus lowest quartiles was 0.51 (95% CI 0.42-0.63; P for trend <0.001). A similar inverse association was observed for vitamin B

conclusionsOur findings suggest that dietary intake of B vitamins, especially riboflavin, vitamin B

Indexed as

DementiaDietFolic AcidRiboflavinVitamin B 12Vitamin B 6Vitamin B ComplexAdultAgedFemaleFollow-Up StudiesHumansIncidenceJapanMaleMiddle AgedFolic AcidRiboflavinVitamin B 12Vitamin B 6Vitamin B Complex

Identifiers

PMID40999064

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.