Observational studyEuropean journal of clinical nutrition2025
Association of a high-protein and low-glycemic-index diet during pregnancy with offspring growth and obesity until the age of 18 years - a target trial emulation.
Observational study in European journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Maternal high-protein/low-glycemic-index diet during pregnancy impairs offspring lipid profile-a randomized controlled trial.European journal of nutrition · 2026Trial
- Associations Between Maternal Pre-Pregnancy Dietary Patterns and Body Composition in Preschool Children: A Prospective Cohort Study.Nutrients · 2026Article
- Nutrition Across the Life Course and Risk of Young-Onset Breast Cancer: Mechanisms, Evidence, and Prevention Opportunities.Nutrients · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMaternal pre-pregnancy BMI and excessive gestational weight gain (GWG) are associated with offspring obesity. Moreover, maternal dietary patterns, particularly protein intake and glycemic index, influence GWG and fetal development. This study aimed to investigate the association of a high-protein, low-glycemic-index (HPLGI) diet during pregnancy with offspring growth and obesity.
methodsUsing observational data from the Danish National Birth Cohort, a target trial emulation was conducted to investigate the association of an HPLGI diet during pregnancy on offspring growth up to 18 years of age. A cohort of 17,551 women who met the inclusion criteria was categorized into exposure groups based on their protein intake and glycemic index to emulate the groups in the APPROACH trial.
resultsMaternal characteristics varied between the exposure groups, with the HPLGI women exhibiting 1.67 kg higher pre-pregnancy weight and 0.49 kg/m
conclusionAn HPLGI diet during pregnancy was associated with higher offspring body weight and BMI at 18 years of age compared to an MPMGI diet. These findings suggest that maternal dietary composition during pregnancy may have long-term implications for offspring growth and obesity risk, underscoring the importance of evaluating dietary recommendations during pregnancy.
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