Evidence map›Paper›PMID 40999048›Full record

ArticleNPJ digital medicine2025

Multimodal foundation model and benchmark for comprehensive retinal OCT image analysis.

José Morano, Botond Fazekas, Emese Sükei, Ronald Fecso, Taha Emre, Markus Gumpinger, Georg Faustmann, Marzieh Oghbaie, Ursula Schmidt-Erfurth, Hrvoje Bogunović

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. AI-driven multimodal retinal imaging for early detection and risk stratification of vascular and neurodegenerative diseases.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
  3. Article
  4. Article
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  9. Article
  10. Benchmarking Vision Encoders for Image Classification in Ophthalmology.Computational and structural biotechnology journal · 2026
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

José MoranoChristian Doppler Laboratory for Artificial Intelligence in Retina, Institute of Artificial Intelligence, Center for Medical Data Science, Medical University of Vienna, Vienna, Austria. jose.moranosanchez@meduniwien.ac.at.
Botond FazekasChristian Doppler Laboratory for Artificial Intelligence in Retina, Institute of Artificial Intelligence, Center for Medical Data Science, Medical University of Vienna, Vienna, Austria.
Emese SükeiOPTIMA Lab, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
Ronald FecsoChristian Doppler Laboratory for Artificial Intelligence in Retina, Institute of Artificial Intelligence, Center for Medical Data Science, Medical University of Vienna, Vienna, Austria.
Taha EmreChristian Doppler Laboratory for Artificial Intelligence in Retina, Institute of Artificial Intelligence, Center for Medical Data Science, Medical University of Vienna, Vienna, Austria.
Markus GumpingerOPTIMA Lab, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
Georg FaustmannChristian Doppler Laboratory for Artificial Intelligence in Retina, Institute of Artificial Intelligence, Center for Medical Data Science, Medical University of Vienna, Vienna, Austria.
Marzieh OghbaieChristian Doppler Laboratory for Artificial Intelligence in Retina, Institute of Artificial Intelligence, Center for Medical Data Science, Medical University of Vienna, Vienna, Austria.
Ursula Schmidt-ErfurthOPTIMA Lab, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
Hrvoje BogunovićChristian Doppler Laboratory for Artificial Intelligence in Retina, Institute of Artificial Intelligence, Center for Medical Data Science, Medical University of Vienna, Vienna, Austria. hrvoje.bogunovic@meduniwien.ac.at.

Funding

Austrian Federal Ministry for Labour and Economy, the National Foundation for Research, Technology and Development, the Christian Doppler Research Association, Heidelberg Engineering, and Austrian Science Fund (FWF) 10.55776/FG9
6 · The paper itself

Abstract

Artificial intelligence (AI) has become a fundamental tool for assisting clinicians in analyzing ophthalmic images, such as optical coherence tomography (OCT). However, developing AI models often requires extensive annotation, and existing models tend to underperform on independent, unseen data. Foundation models (FMs), large AI models trained on vast, unlabeled datasets, have shown promise in overcoming these challenges. Nonetheless, available FMs for ophthalmology lack extensive validation, especially for segmentation tasks, and focus on a single imaging modality. In this context, we propose MIRAGE, a novel multimodal FM for the analysis of OCT and scanning laser ophthalmoscopy (SLO) images. Additionally, we propose a new evaluation benchmark with OCT/SLO classification and segmentation tasks. The comparison with general and specialized FMs and segmentation methods shows the superiority of MIRAGE in both types of tasks, highlighting its suitability as a basis for the development of robust AI systems for retinal OCT image analysis.

Identifiers

PMID40999048
PMCPMC12462498

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.