Evidence map›Paper›PMID 40999036›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Correlation between polymorphisms of the aquaporin-1 gene and peritoneal function in children on chronic peritoneal dialysis.

Jiani Yao, Chunyan Wang, Xiaoyan Fang, Jing Chen, Zhiqing Zhang, Jiaojiao Liu, Jialu Liu, Rufeng Dai, Xiaotian Chen, Yihui Zhai and 2 more

Abstract read
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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiani YaoDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Chunyan WangDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Xiaoyan FangDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Jing ChenDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Zhiqing ZhangDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Jiaojiao LiuDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Jialu LiuDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Rufeng DaiDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Xiaotian ChenDepartment of Clinical Epidemiology & Clinical Trial Unit, Children's Hospital of Fudan University, Shanghai, China.
Yihui ZhaiDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Hong XuDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. hxu@shmu.edu.cn.
Qian ShenDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. shenqian@shmu.edu.cn.ORCID http://orcid.org/0000-0003-3056-6737

Funding

Key Technologies Research and Development Program 2022YFC2705100Key Technologies Research and Development Program 2022YFC2705105
6 · The paper itself

Abstract

backgroundAquaporins (AQPs) are a class of proteins that transport water molecules across membranes, which can promote water transport in cells. We aimed to explore the correlation between different polymorphisms of AQP1 and peritoneal function in children on peritoneal dialysis (PD).

methodsChildren who underwent PD at the Children's Hospital of Fudan University from January 1, 2014, to December 31, 2023, were included. The AQP1 genotypes of the four polymorphisms were rs2075574 (TT, CT, CC), rs1049305 (GG, CG, CC), rs10253374 (TT, CT, CC) and rs17159702 (TT, CT, CC).

resultsA total of 187 children on chronic PD were included in the study. We found that the TT group with rs2075574 exhibited a lower baseline peritoneal equilibration test (PET) ultrafiltration level than the CC group (302 ± 129 vs. 408 ± 168 ml/m

conclusionsAQP1 rs2075574 and rs1049305 polymorphisms might be associated with ultrafiltration and urea transport in children with PD.

Indexed as

Aquaporin 1Kidney Failure, ChronicPeritoneal DialysisPeritoneumAdolescentChildChild, PreschoolFemaleGenotypeHumansMalePolymorphism, Single NucleotideRetrospective StudiesAQP1 protein, humanAquaporin 1ChildrenGenetic polymorphismPeritoneal dialysisPeritoneal function

Identifiers

PMID40999036

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.