Evidence map›Paper›PMID 40999030›Full record

ArticleNature aging2025

A distinct population of CD8

Monica Bodogai, Bongsoo Park, Fatima-Zohra Braikia, Fnu Naqing, Konda Kumaraswami, Chen Chen, Emeline Ragonnaud, Sharon Stack, Steffen Ormanns, Michael Günther and 7 more

Abstract read
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In one paragraph

Article in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
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  5. Review
  6. Aging and lung diseases: Unraveling mechanisms and therapeutic targets.Chinese medical journal pulmonary and critical care medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Monica BodogaiImmunoregulation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.
Bongsoo ParkEpigenetics and Stem Cell Aging Unit, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Fatima-Zohra BraikiaGene Regulation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.
Fnu NaqingCenter for Human Genetics, Department of Genetics and Biochemistry, Clemson University, Clemson, SC, USA.
Konda KumaraswamiImmunoregulation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.
Chen ChenImmunoregulation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.
Emeline RagonnaudImmunoregulation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.
Sharon StackHarper Cancer Research Institute, Department of Chemistry and Biochemistry, University of Notre Dame, South Bend, IN, USA.
Steffen OrmannsInstitute of General Pathology, Medical University Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-0754-9034
Michael GüntherInstitute of General Pathology, Medical University Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0009-0001-5091-5060
Hellen Ishikawa-AnkerholdDepartment of Medicine I, University Hospital, Ludwig Maximilians Universität München, Munich, Germany.
Supriyo DeComputational Biology and Genomics Core, National Institute on Aging, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-2075-7655
Luigi FerrucciLongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-6273-1613
Ranjan SenGene Regulation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-1916-3905
Zhana DurenCenter for Human Genetics, Department of Genetics and Biochemistry, Clemson University, Clemson, SC, USA.
Isabel BeermanEpigenetics and Stem Cell Aging Unit, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-7758-8231
Arya BiragynImmunoregulation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA. biragyna@mail.nih.gov.ORCID http://orcid.org/0000-0001-5276-6102

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related increases in cancer have traditionally been attributed to compromised antitumor immunity of exhausted and dysfunctional CD8⁺ T cells. Here we provide an alternative mechanism: in aging, cancer also progresses with the help of fully functional CD8⁺ T cells. These transcriptionally and epigenetically distinct cells (termed double-positive CD8

Indexed as

5'-NucleotidaseAgingAntigens, CDApyraseCD8-Positive T-LymphocytesNeoplasmsAnimalsDisease ProgressionFemaleHumansMiceMice, Inbred C57BL5'-NucleotidaseAntigens, CDApyraseCD39 antigen

Identifiers

PMID40999030

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.