Evidence map›Paper›PMID 40998954›Full record

ArticleScientific reports2025

Conjugated bile acids in serum reflect disease severity and predict survival in chronic liver disease of humans and rats.

Akiko Eguchi, Motoh Iwasa, Teruo Miyazaki, Mina Tempaku, Masako Ichishi, Yasuyuki Tamai, Ryuta Shigefuku, Yoshinao Kobayashi, Akira Honda, Masatoshi Watanabe and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Conjugated Bile Acids Profile Suggests a Novel Liver-Muscle Axis Associated With Sarcopenia in Chronic Liver Disease.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Akiko EguchiDepartment of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan. akieguchi@med.mie-u.ac.jp.
Motoh IwasaDepartment of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan.
Teruo MiyazakiJoint Research Center, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Mina TempakuDepartment of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan.
Masako IchishiDepartment of Oncologic Pathology, Mie University Graduate School of Medicine, Tsu, Japan.
Yasuyuki TamaiDepartment of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan.
Ryuta ShigefukuDepartment of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan.
Yoshinao KobayashiDepartment of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan.
Akira HondaJoint Research Center, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Masatoshi WatanabeBiobank Center, Mie University Hospital, Tsu, Japan.
Tadashi IkegamiDepartment of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Hayato NakagawaDepartment of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan.

Funding

Japan Agency for Medical Research and Development JP21fk0210090JSPS KAKENHI 22K08011
6 · The paper itself

Abstract

Chronic liver diseases (CLD) are closely linked to an increased load of conjugated bile acids (BAs), which contribute to liver damage and inflammation, although many aspects remain unclear. This study investigated the relationships between serum conjugated BAs, BA-related gene expression in the liver and ileum, and survival outcomes in both human and rat models of CLD. Serum BA levels, including tauro- and glyco-conjugated BAs such as taurochenodeoxycholic acid (TCDCA), were measured in 73 CLD patients and in carbon tetrachloride (CCl

Indexed as

Bile Acids and SaltsLiver DiseasesAdultAgedAnimalsBiomarkersCarbon TetrachlorideChronic DiseaseDisease Models, AnimalFemaleHumansLiverMaleMiddle AgedPrognosisRatsBile Acids and SaltsBiomarkersCarbon TetrachlorideTaurochenodeoxycholic AcidBaat geneConjugated bile acidFibrogenesisLiver cirrhosisSlc10a2 geneSurvivalTaurochenodeoxycholic acid

Identifiers

PMID40998954
PMCPMC12464243

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.