Evidence map›Paper›PMID 40998915›Full record

ArticleScientific reports2025

A novel HPβCD-Cu(DDC)

Hamid Suhail, Md Ataur Rahman, Mahesh Kumar Yadab, Sunalee Gonawala, Ana deCarvalho, James R Ewing, James Snyder, Meser M Ali

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hamid SuhailDepartment of Neurosurgery, Henry Ford Health, Detroit, MI, 48202, USA.
Md Ataur RahmanDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, 48201, USA.
Mahesh Kumar YadabDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, 48201, USA.
Sunalee GonawalaDepartment of Neurosurgery, Henry Ford Health, Detroit, MI, 48202, USA.
Ana deCarvalhoDepartment of Neurosurgery, Henry Ford Health, Detroit, MI, 48202, USA.
James R EwingDepartment of Neurosurgery, Henry Ford Health, Detroit, MI, 48202, USA.
James SnyderDepartment of Neurosurgery, Henry Ford Health, Detroit, MI, 48202, USA.
Meser M AliDepartment of Neurosurgery, Henry Ford Health, Detroit, MI, 48202, USA. meser92@wayne.edu.

Funding

Targeted drug delivery system to overcome blood-brain barrier and therapeutic resistance to current standard of care in GlioblastomaR01CA269607 · NCI · WAYNE STATE UNIVERSITY · PI Meser M. Ali · 2023 to 2026
$2.0M
NCI NIH HHS R01 CA269607NIH HHS RO1CA269607
6 · The paper itself

Abstract

The uniform lethality of glioblastoma (GBM) with a survival of less than 2 years despite best available therapy is attributed to treatment resistance due to DNA repair mechanisms that drive disease relapse and tumor heterogeneity. One prognostic factor identified as a reliable biomarker for GBM sensitivity to temozolomide (TMZ) and radiotherapy (RT) is the overexpression of O

Indexed as

Brain NeoplasmsCopperDNA Modification MethylasesDNA Repair EnzymesDrug Delivery SystemsDrug Resistance, NeoplasmGlioblastomaTemozolomideTumor Suppressor ProteinsAnimalsAntineoplastic Agents, AlkylatingCell Line, TumorDisulfiramHumansMiceXenograft Model Antitumor AssaysAntineoplastic Agents, AlkylatingCopperDisulfiramDNA Modification MethylasesDNA Repair EnzymesMGMT protein, humanTemozolomideTumor Suppressor Proteins2-Hydroxypropyl beta cyclodextrin (HPβCD)Brain tumorDisulfiram (DSF)Glioblastoma (GBM)O6-methylguanine-methyltransferase (MGMT)Temozolomide (TMZ)Ubiquitin-proteasome pathway

Identifiers

PMID40998915
PMCPMC12464313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.