ArticleNPJ vaccines2025
A multivalent mRNA-LNP cocktail vaccine confers superior efficacy against Staphylococcus aureus infection in murine models.
Article in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Bacterial mRNA Vaccines: Programming Immunity Against Antimicrobial Resistance.Drug development research · 2026Review
- Article
- PLGA-PEG Nano-Adjuvant-Delivered ClfA Vaccine Elicits IL-17A-Mediated Neutrophil Activation to Confer Complete Protection Against Methicillin-ResistantInternational journal of nanomedicine · 2026Article
- Taming Superbugs: Current Progress and Challenges in Combating ESKAPE Pathogens.Pathogens (Basel, Switzerland) · 2025Review
- An integrated subtractive genomics and immunoinformatic approach for designing a multi-epitope peptide vaccine against methicillin-resistantFrontiers in bioinformatics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Staphylococcus aureus has been posing a significant global health threat, underscoring an urgent need for innovative preventive strategies, notably vaccines. This study presents an evaluation of a multi-target mRNA vaccine against S. aureus, engineered to target five pivotal virulence factors: the manganese transporter MntC, enterotoxin SEB, exotoxin HLA, adhesion factor FnBPA, and iron surface binding protein IsdB. In a parallel control setting, mice were immunized with either monovalent mRNA-LNPs, a multivalent mRNA-LNP cocktail, or a protein cocktail, and were subsequently assessed for humoral and cellular immune responses as well as the vaccines' protective efficacy. The findings demonstrated that the multivalent mRNA-LNP cocktail vaccine induced a robust and sustained humoral immune response, along with a stronger cellular immune response compared to both monovalent mRNA vaccines and the protein cocktail vaccine. This was characterized by increased secretion of IFN-γ, IL-2, IL-4, and IL-17A, suggesting a potent Th1/Th2/Th17 mixed immune response. Moreover, the cocktail vaccine demonstrated improved survival rates and a reduction in bacterial loads and organ damage. These results underscore the promise of a multi-target mRNA vaccine strategy in combating antibiotic-resistant Staphylococcus aureus.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.