Evidence map›Paper›PMID 40998770›Full record

ArticleNature communications2025

Complex carbohydrate utilization by gut bacteria modulates host food consumption.

Kristie B Yu, Celine Son, Ezgi Özcan, Anisha Chandra, Jorge Paramo, Andrew Varghese, Alicia Roice, Delanie Finnigan, Franciscus Chandra, Anna Novoselov and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Gut microbes · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Kristie B YuDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA. kbyu@mednet.ucla.edu.ORCID http://orcid.org/0000-0001-6735-3968
Celine SonDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Ezgi ÖzcanDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-5365-1550
Anisha ChandraDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Jorge ParamoUCLA Goodman-Luskin Microbiome Center, Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, Los Angeles, CA, USA.
Andrew VargheseDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Alicia RoiceDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Delanie FinniganDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Franciscus ChandraDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Anna NovoselovDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Sabeen A KazmiDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-3913-6170
Gregory R LumDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Arlene Lopez-RomeroUCLA Goodman-Luskin Microbiome Center, Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, Los Angeles, CA, USA.ORCID http://orcid.org/0009-0005-1141-713X
Jonathan B LynchDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-5221-7090
Elaine Y HsiaoDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA. ehsiao@g.ucla.edu.ORCID http://orcid.org/0000-0002-1633-588X

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
New York Stem Cell Foundation (NYSCF) Robertson InvestigatorNIGMS NIH HHS T32 GM008042W. M. Keck Foundation (W.M. Keck Foundation) 995336
6 · The paper itself

Abstract

The gut microbiota interacts with dietary nutrients and can modify host feeding behavior, but underlying mechanisms remain poorly understood. Gut bacteria digest complex carbohydrates that the host cannot digest and liberate metabolites that serve as energy sources and signaling molecules. Here, we use a gnotobiotic mouse model to examine how gut bacterial fructose polysaccharide metabolism influences host intake of diets containing these carbohydrates. Two Bacteroides species ferment fructans with different glycosidic linkages: B. thetaiotaomicron ferments levan with β2-6 linkages, whereas B. ovatus ferments inulin with β2-1 linkages. We find that mice eat relatively more diet containing the carbohydrate that their gut bacteria cannot ferment compared to the fermentable ones: mice colonized with B. thetaiotaomicron consume more inulin diet, while mice colonized with B. ovatus consume more levan diet. Knockout of bacterial fructan utilization genes attenuates this difference, whereas swapping the fermentation ability of B. thetaiotaomicron to inulin confers increased consumption of levan diet. Bacterial fructan fermentation and host feeding behavior are associated with neuronal activation in the arcuate nucleus of the hypothalamus. These results reveal that bacteria nutrient metabolism modulates host food consumption through sensing of differential energy extraction, which contributes to our understanding of determinants of food choice.

Indexed as

BacteroidesFeeding BehaviorGastrointestinal MicrobiomeAnimalsDietary CarbohydratesFermentationFructansFructoseGerm-Free LifeInulinMaleMiceMice, Inbred C57BLDietary CarbohydratesFructansFructoseInulinlevan

Identifiers

PMID40998770
PMCPMC12462444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.