ArticleObesity (Silver Spring, Md.)2025
Time-Restricted Access to High-Fat Diet Influences Weight Gain, Meal Patterns, and Food Preference.
Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Hepatic ketogenic insufficiency blunts exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle.Function (Oxford, England) · 2026Article
- Time-Restricted Access to High-Fat Diet Influences Weight Gain, Meal Patterns, and Food Preference.Obesity (Silver Spring, Md.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveAccess to only high-fat diet (HFD) during the light versus dark cycle promotes different metabolic outcomes. We assessed changes in body weight/composition, feeding behavior, and metabolic parameters in mice fed HFD during the light or dark cycle with concomitant ad libitum access to chow.
methodsMale C57BL/6J mice were housed in metabolic chambers with two hoppers containing chow. HFD was then provided in one hopper, with access restricted to the light or dark cycle. The other hopper provided ad libitum access to chow. Food intake, meal patterns, energy expenditure, activity, and substrate oxidation were measured for ~4 weeks. Body weight/composition was measured before and after ~4-week HFD access.
resultsLight cycle HFD access promoted greater weight and fat mass gain. Although daily caloric intake was equivalent between groups, light cycle HFD access increased preference for HFD and intake of larger, more frequent HFD meals during the daytime. Dark cycle HFD access promoted preference for chow and consumption of larger, more frequent chow meals.
conclusionsLight cycle HFD access parallels detrimental metabolic outcomes of ad libitum HFD access. Dark cycle HFD access reduces weight gain and adiposity; this is associated with enhanced chow preference.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.