Evidence map›Paper›PMID 40998407›Full record

ReviewJournal of natural products2025

The Role of Nucleotide Sequencing in Natural Product Drug Discovery.

Samantha C Waterworth

Abstract readReview
In one paragraph

Review in Journal of natural products, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Samantha C WaterworthMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States.ORCID 0000-0001-6436-0142

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For millennia, humans have drawn upon natural sources for medicinal remedies. However, the discovery process was often a serendipitous endeavor, and the true biosynthetic potential of the planet's biodiversity remained largely hidden. The advent of nucleotide sequencing offered a pivotal shift, providing tools to decipher the cryptic codes within biosynthetic machinery. In this Perspective, I describe the arc of the sequencing era, from its foundational impact to the current landscape of sophisticated bioinformatic tools. Furthermore, I will address the international legal frameworks being implemented to protect the very biodiversity upon which the field of natural product discovery relies.

Indexed as

Biological ProductsDrug DiscoverySequence Analysis, DNAComputational BiologyHumansBiological Productsbiodiversitybiosynthesisdrug discoverynatural products

Identifiers

PMID40998407
PMCPMC12560086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.