Evidence map›Paper›PMID 40998300›Full record

ArticleJournal of natural products2025

Actinomycetoquinones A-E, Anthraquinone-γ-Pyrones Discovered from Marine-Derived

Fan Zhang, Christopher D Roberts, Tae Hyun Lee, Doug R Braun, Zachary D Bennett, Shaurya Chanana, Song Guo, Gene E Ananiev, Ilia A Guzei, Scott R Rajski and 2 more

Abstract read
In one paragraph

Article in Journal of natural products, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fan ZhangPharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0001-9732-1123
Christopher D RobertsPharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Tae Hyun LeePharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Doug R BraunPharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Zachary D BennettDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0001-5407-1523
Shaurya ChananaPharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Song GuoSmall Molecule Screening Facility, UW Carbone Cancer Center, Madison, Wisconsin 53706, United States.
Gene E AnanievSmall Molecule Screening Facility, UW Carbone Cancer Center, Madison, Wisconsin 53706, United States.
Ilia A GuzeiDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0003-1976-7386
Scott R RajskiPharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Thomas C BrunoldDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0001-6516-598X
Tim S BugniPharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0002-4502-3084

Funding

Novel antimicrobials targeting MDR pathogens from animal microbial symbiontsU19AI142720 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ANDES, DAVID R · 2019 to 2023
$30.1M
NMR User Program at NMRFAMR24GM141526 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Katherine Anne Henzler-Wildman · 2021 to 2026
$6.4M
Chemistry-Biology Interface Training ProgramT32GM152341 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Helen E. Blackwell · 2024 to 2026
$1.6M
ACQUISITION OF MASS SPECTROMETER FOR CORE FACILITYS10RR013790 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI RAINES, RONALD T · 1999 to 1999
–
NCRR NIH HHS S10 RR013790NIAID NIH HHS U19 AI142720NIGMS NIH HHS R24 GM141526NIGMS NIH HHS T32 GM152341
6 · The paper itself

Abstract

Facilitated by LC-MS-PCA metabolomics methods and effective molecular networking for strain prioritization and dereplication, five new anthraquinone-γ-pyrones, actinomycetoquinones A-E (

Indexed as

ActinobacteriaAnthraquinonesAnti-Bacterial AgentsPyronesCrystallography, X-RayEscherichia coliMarine BiologyMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular StructureNuclear Magnetic Resonance, BiomolecularAnthraquinonesAnti-Bacterial AgentsPyrones

Identifiers

PMID40998300
PMCPMC12503092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.