Evidence map›Paper›PMID 40998052›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2026

Increased rate of deceased donor liver transplantation for candidates willing to receive organs from donors with human immunodeficiency virus.

Zeba Nauroz, Sander Florman, Meenakshi M Rana, Jennifer D Motter, Jennifer C Price, Sapna A Mehta, Jonathan Hand, David Wojciechowski, Saima Aslam, Maricar Malinis and 14 more

Abstract readMulticenter Study
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Potential pool of cardiothoracic organs from donors with HIV.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Zeba NaurozDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Sander FlormanDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Meenakshi M RanaDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jennifer D MotterDepartment of Surgery, NYU Grossman School of Medicine, New York, USA.
Jennifer C PriceDepartement of Medicine, University of California, San Francisco, San Francisco, California, USA.
Sapna A MehtaDepartment of Medicine, NYU Grossman School of Medicine, New York, USA.
Jonathan HandDepartment of Medicine, Ochsner Health, New Orleans, Louisiana, USA.
David WojciechowskiDepartment of Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
Saima AslamDepartment of Medicine, University of California San Diego, La Jolla, California, USA.
Maricar MalinisDepartment of Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Nahel EliasDepartment of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA.
Ghady HaidarDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Marcus R PereiraDepartment of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Jacques SimkinsDepartment of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Valentina StosorDivision of Infectious Disease and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Catherine B SmallDepartment of Medicine/ Division of Infectious Disease, Weill Cornell Medicine, New York, New York, USA.
John BaddleyDepartment of Medicine, University of Maryland, Baltimore, Maryland, USA.
Senu ApewokinDepartment of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, USA.
Megan MorsheimerDivision of Allergy, Immunology and Infectious Diseases, National Institute of Health, Bethesda, Maryland, USA.
Aaron A R TobianDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Medicine, Johns hopkins School of Medicine, Baltimore, Maryland, USA.
Dorry L SegevDepartment of Surgery, NYU Grossman School of Medicine, New York, USA.
Christine M DurandDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Medicine, Johns hopkins School of Medicine, Baltimore, Maryland, USA.
Allan B MassieDepartment of Surgery, NYU Grossman School of Medicine, New York, USA.
Mary G BowringDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. Electronic address: mbowrin1@jhmi.edu.

Funding

HOPE in Action: A Clinical Trial of HIV-to-HIV Liver TransplantationU01AI138897 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Christine Marie Durand, DORRY L. SEGEV · 2018 to 2026
$25.5M
Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Kidney Transplantation from Donors with HIV: Impact on Rejection and Long-term OutcomesU01AI177211 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Christine Marie Durand, DORRY L. SEGEV · 2023 to 2026
$6.9M
Unlocking the Potential of HIV-Infected Deceased Donors for Organ TransplantationR01AI120938 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOBIAN, AARON A · 2016 to 2021
$4.3M
T-cell depletion and maintenance of the HIV-1 latent reservoir in distinct tissue compartmentsR01DK131926 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Melissa Laird Smith, AARON A TOBIAN · 2022 to 2026
$3.6M
Harnessing Induced Human Intestinal Organoids (iHIOs) and Metagenomics to Unravel Host Immune-microbiota Interactions During Cancer Chemotherapy-associated Clostridium difficile InfectionsK08CA237735 · NCI · UNIVERSITY OF CINCINNATI · PI APEWOKIN, SENU · 2020 to 2024
$1.1M
Leveraging a novel health records platform to predict the development of cardiovascular disease following kidney transplantationF30HL168842 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BOWRING, MARY GRACE · 2023 to 2025
$170k
NCI NIH HHS K08 CA237735NHLBI NIH HHS F30 HL168842NIAID NIH HHS R01 AI120938NIAID NIH HHS U01 AI138897NIAID NIH HHS U01 AI177211NIDDK NIH HHS R01 DK131926NIGMS NIH HHS T32 GM136577
6 · The paper itself

Abstract

Historically, liver transplant (LT) candidates with human immunodeficiency virus (HIV) have experienced high waitlist mortality. Since the HIV Organ Policy Equity (HOPE) Act expands access to organs from donors with HIV, we assessed the impact of HOPE on LT rate and wait time for this population. We linked data from a multicenter HOPE in Action study to Scientific Registry of Transplant Recipients (February 21, 2019 to June 1, 2024) and used Poisson regression to compare transplant rates among 99 candidates willing to accept HOPE donors (HOPE candidates) to 13 495 candidates with or without HIV not listed as willing to accept HOPE donors (non-HOPE candidates) matched on transplant center. The median time to any deceased donor liver transplant (DDLT) was 2.3 months for HOPE and 1.1 years for non-HOPE candidates. Within 2 years of listing, 90.9% of HOPE versus 58.5% of non-HOPE candidates received a DDLT (P < .001). HOPE was associated with an overall 3.11-fold higher DDLT incident rate ratio (95% CI 2.48-3.88, P < .001). Stratified by model for end-stage liver disease score categories 6 to 14, 15 to 24, 25 to 34, and 35 to 40/status 1; HOPE candidates had 10.12-fold, 5.31-fold, 1.41-fold and 2.90-fold higher DDLT rates, respectively. Willingness to accept livers from donors with HIV improves access to liver transplantation for candidates with HIV.

Indexed as

Donor SelectionEnd Stage Liver DiseaseHIVHIV InfectionsLiver TransplantationTissue and Organ ProcurementTissue DonorsAdultFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRegistriesWaiting ListsHIVHOPE in ActionLiver transplant

Identifiers

PMID40998052
PMCPMC12606687

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.