ArticleRenal failure2025
Low-dose loop diuretics improve survival and renal function in cancer patients with early-stage sepsis-associated acute kidney injury.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sepsis often causes sepsis-associated acute kidney injury (S-AKI) and is a leading cause of death in critically ill cancer patients. This study aims to assess the prognostic value of loop diuretic use in cancer patients with S-AKI. A retrospective cohort of 117 cancer patients with S-AKI admitted to the ICU between 2009 and 2023 was analyzed. Among them, 90 patients treated with loop diuretics were categorized into four groups according to AKI stage and furosemide dose: early-stage with low-dose, early-stage with high-dose, late-stage with low-dose, and late-stage with high-dose. Additionally, 27 early-stage patients who did not receive diuretics were included as a comparator group. The primary outcome was 28-day mortality. Patients receiving low-dose furosemide at early-stage AKI had significantly lower 28-day mortality (22.7%,
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