Evidence map›Paper›PMID 40997786›Full record

ArticleThe American journal of tropical medicine and hygiene2025

Toward Setting Minimum and Optimal Data to Report for Malaria Molecular Surveillance with Targeted Sequencing: The "What" and "Why".

Jonathan J Juliano, Cecile P G Meier-Scherling, Neeva Wernsman Young, George A Tollefson, Sean V Connelly, Jonathan B Parr, Melissa D Conrad, Jacob M Sadler, Christopher M Hennelly, Ashenafi Assefa and 12 more

Abstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Mapping the prevalence of molecular markers ofmedRxiv : the preprint server for health sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Jonathan J JulianoDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina.
Cecile P G Meier-ScherlingCenter for Computational Molecular Biology, Brown University, Providence, Rhode Island.
Neeva Wernsman YoungCenter for Computational Molecular Biology, Brown University, Providence, Rhode Island.
George A TollefsonCenter for Computational Molecular Biology, Brown University, Providence, Rhode Island.
Sean V ConnellyMD-PhD Program, School of Medicine, University of North Carolina, Chapel Hill, North Carolina.
Jonathan B ParrDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina.
Melissa D ConradDepartment of Medicine, University of California- San Francisco, San Francisco, California.
Jacob M SadlerDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina.
Christopher M HennellyDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina.
Ashenafi AssefaDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina.
Lucy OkellMRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College, London, United Kingdom.
Abebe A FolaDepartment of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island.
Karamoko NiaréDepartment of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island.
Jacob MarglousCenter for Computational Molecular Biology, Brown University, Providence, Rhode Island.
Kelly Carey-EwendInstitute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina.
Ronald Futila Kyong-ShinCurriculum in Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, North Carolina.
Isabela Gerdes GyuriczaCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina.
Gina Cuomo-DannenburgMRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College, London, United Kingdom.
Shazia Ruybal-PesántezMRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College, London, United Kingdom.
Oliver J WatsonMRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College, London, United Kingdom.
Robert VerityMRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College, London, United Kingdom.
Jeffrey A BaileyCenter for Computational Molecular Biology, Brown University, Providence, Rhode Island.

Funding

Tracking the flow of malaria parasites and drug resistance within the DRC and across its bordersR01AI139520 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BAILEY, JEFFREY A. · 2018 to 2023
$3.6M
After the flood: Optimal strategies to prevent malaria epidemics caused by severe floodingR01AI173558 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ross Mathew Boyce · 2023 to 2026
$3.6M
Epidemiology and determinants of emerging artemisinin-resistant malaria in EthiopiaR01AI177791 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan Boyd Parr · 2023 to 2026
$3.2M
Artemisinin Resistance in Africa: its emergence and evolution in RwandaR01AI156267 · NIAID · BROWN UNIVERSITY · PI BAILEY, JEFFREY A., JULIANO, JONATHAN J · 2021 to 2024
$3.0M
Surveillance to track and characterize antimalarial resistance trends in Ugandan Plasmodium falciparum parasites (STARTUP)R01AI173557 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Melissa D Conrad · 2023 to 2026
$2.9M
Importation and transmission of malaria in Zanzibar: a case study for eliminationR01AI155730 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JULIANO, JONATHAN J, LIN, JESSICA · 2021 to 2024
$2.8M
Mentoring in Translational Malaria GenomicsK24AI134990 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan J Juliano · 2018 to 2026
$1.6M
Investigating the molecular mechanisms of Plasmodium vivax invasion in Duffy-negative hostsF30AI183592 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Sean Connelly · 2024 to 2026
$130k
NIAID NIH HHS F30 AI183592NIAID NIH HHS K24 AI134990NIAID NIH HHS R01 AI139520NIAID NIH HHS R01 AI155730NIAID NIH HHS R01 AI156267NIAID NIH HHS R01 AI173557NIAID NIH HHS R01 AI173558NIAID NIH HHS R01 AI177791
6 · The paper itself

Abstract

The coronavirus disease 2019 pandemic showcased the power of genomic surveillance in tracking infectious diseases, driving rapid public health responses, and global collaboration. This same infrastructure is being leveraged for malaria molecular surveillance (MMS) in Africa to address challenges such as artemisinin partial resistance and deletions in the Plasmodium falciparum histidine-rich protein 2 and 3 genes. However, variability in reporting sequencing methods and data reporting currently limits the validation, comparability, and reuse of data. To maximize the impact of MMS, minimal and optimal data that are key for validation and maximizing transparency and findable, accessible, interoperable, and reusable principles are proposed for reporting. Rather than focusing on specific data formats, in the current study, the authors propose what should be reported and why. Progressing to reporting individual infection-level polymorphism or microhaplotype data is central to maximizing the impact of MMS. Reporting must adhere to local regulatory practices and ensure proper data oversight and management, preventing data colonialism and preserving opportunities for data generators. With malaria's challenges transcending borders, reporting and adopting standardized practices are essential to advancing research and strengthening global public health efforts.

Indexed as

MalariaMalaria, FalciparumPlasmodium falciparumAfricaAntimalarialsArtemisininsCOVID-19Drug ResistanceHumansProtozoan ProteinsSARS-CoV-2AntimalarialsArtemisininsProtozoan Proteins

Identifiers

PMID40997786
PMCPMC12676599

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.