Continuous Flow Techniques in the Total Synthesis of Jaspine B: Part II.

Michal Gurský, Dorotea Trnovcová, Pavol Lopatka, Martin Markovič, Peter Koóš, Steven V Ley, Tibor Gracza

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Article in The Journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Michal GurskýInstitute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, SK-812 37 Bratislava, Slovak Republic.

Dorotea TrnovcováInstitute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, SK-812 37 Bratislava, Slovak Republic.

Pavol LopatkaInstitute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, SK-812 37 Bratislava, Slovak Republic.

Martin MarkovičInstitute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, SK-812 37 Bratislava, Slovak Republic.ORCID 0000-0002-4843-1075

Peter KoóšInstitute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, SK-812 37 Bratislava, Slovak Republic.ORCID 0000-0003-3091-7699

Steven V LeyYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.ORCID 0000-0002-7816-0042

Tibor GraczaInstitute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, SK-812 37 Bratislava, Slovak Republic.ORCID 0000-0002-7667-0663

Funding

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6 · The paper itself

Abstract

In this work, we report on the completion of the total synthesis of jaspine B from Garner's aldehyde using a Pd-catalyzed carbonylation strategy under continuous flow conditions. The target compound was synthesized from the key intermediate bicyclic aminolactone

Identifiers

PMID40997776

DOI10.1021/acs.joc.5c01799

PMCPMC12519474

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