Evidence map›Paper›PMID 40997552›Full record

ArticleAddictive behaviors2026

Reactivity to electronic nicotine delivery system (ENDS) cues in adults who smoke cigarettes and vape cannabis.

Krista Miloslavich, Emma I Brett, Daniel J Fridberg, Andrea C King

Abstract read
In one paragraph

Article in Addictive behaviors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Krista MiloslavichUniversity of Illinois Chicago, Department of Psychology, Chicago, IL, USA.
Emma I BrettUniversity of Chicago, Department of Psychiatry and Behavioral Neuroscience, Chicago, IL, USA.
Daniel J FridbergUniversity of Chicago, Department of Psychiatry and Behavioral Neuroscience, Chicago, IL, USA.
Andrea C KingUniversity of Chicago, Department of Psychiatry and Behavioral Neuroscience, Chicago, IL, USA.

Funding

Alcohol Research Training in epigenetics and pathophysiology (ARTEP)T32AA026577 · NIAAA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SUBHASH C. PANDEY · 2019 to 2026
$2.7M
E-cigarette use as a smoking cueR01DA044210 · NIDA · UNIVERSITY OF CHICAGO · PI KING, ANDREA C · 2018 to 2021
$2.1M
Development of a mobile health intervention for electronic cigarette use among young adultsR00DA054260 · NIDA · UNIVERSITY OF CHICAGO · PI Emma Brett · 2024 to 2026
$747k
Development of a mobile health intervention for electronic cigarette use among young adultsK99DA054260 · NIDA · UNIVERSITY OF CHICAGO · PI BRETT, EMMA · 2022 to 2023
$346k
NIAAA NIH HHS T32 AA026577NIDA NIH HHS K99 DA054260NIDA NIH HHS R00 DA054260NIDA NIH HHS R01 DA044210
6 · The paper itself

Abstract

introductionPrior research shows that in-person exposure to electronic nicotine delivery systems (ENDS) use increases desire for both cigarettes and ENDS. Distinct from nicotine ENDS use, cannabis vaping is on the rise, often in conjunction with nicotine vaping or combustible cigarettes, marking a need to understand how co-use impacts ENDS cue reactivity. This study leverages a remote cue-delivery paradigm to evaluate the impact of co-use of cigarettes and cannabis on reactivity to a remote ENDS cue.

methodsA cannabis co-use group (N = 45, individuals who smoke cigarettes and vape cannabis) and a non-co-use group (n = 61, individuals who smoke cigarettes and do not vape cannabis) observed a study confederate drinking bottled water (control cue) and vaping an ENDS (active cue). Desire to use a cigarette, ENDS and cannabis were measured before the cues (baseline), post-water and post-ENDS cue.

resultsMultilevel models, controlling for sex and weekly ENDS use, examined cue reactivity across the co-use and non-co-use groups. Those who vaped cannabis in the past year reported both higher baseline ENDS and cannabis desire and heightened responses to the ENDS cue such that cue exposure significantly increased their desire for cigarettes, ENDS and cannabis.

conclusionsThis study provides the first evidence for differential ENDS cue-elicited desire in those who smoke cigarettes and vape cannabis. These findings suggest that co-use of cannabis and cigarettes may increase vulnerability to cravings, indicating a need for tailored prevention and intervention strategies for individuals who use both substances.

Indexed as

Cigarette SmokingCravingCuesElectronic Nicotine Delivery SystemsMarijuana SmokingVapingAdolescentAdultFemaleHumansMaleYoung Adult

Identifiers

PMID40997552
PMCPMC12863422

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.