Evidence map›Paper›PMID 40997375›Full record

ArticleVaccine2025

Nontoxic, multi-domain botulinum neurotoxin-LCHC

A Przedpelski, W H Tepp, S Gupta, J T Barbieri, S Pellett

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

A PrzedpelskiMedical College of Wisconsin, 8701 Watertown Plank Rd., Microbiology and Immunology, Milwaukee, WI 53226, United States of America.
W H TeppUniversity of Wisconsin-Madison, Department of Bacteriology, Microbial Sciences Building, 1550 Linden Dr. Madison, WI, United States of America.
S GuptaUniversity of Wisconsin-Madison, Department of Bacteriology, Microbial Sciences Building, 1550 Linden Dr. Madison, WI, United States of America.
J T BarbieriMedical College of Wisconsin, 8701 Watertown Plank Rd., Microbiology and Immunology, Milwaukee, WI 53226, United States of America. Electronic address: jtb01@mcw.edu.
S PellettUniversity of Wisconsin-Madison, Department of Bacteriology, Microbial Sciences Building, 1550 Linden Dr. Madison, WI, United States of America. Electronic address: sabine.pellett@wisc.edu.

Funding

Vaccines Against BotulismR01AI118389 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, PELLETT, SABINE · 2015 to 2024
$6.1M
NIAID NIH HHS R01 AI118389
6 · The paper itself

Abstract

Botulinum neurotoxins (BoNTs), the causative agents of botulism, are proteins consisting of an N-terminal catalytic Light Chain (LC) and a C-terminal Heavy Chain (HC), which comprises a LC-translocation domain (HC

Indexed as

Bacterial VaccinesBotulinum ToxinsBotulismAnimalsAntibodies, BacterialAntibodies, NeutralizingFemaleImmunoglobulin GMiceMice, Inbred BALB CAntibodies, BacterialAntibodies, NeutralizingBacterial VaccinesBotulinum ToxinsImmunoglobulin GBotulinum toxinBotulismGenetically engineered-vaccineImmunogenicitySelect-agent vaccineToxinVaccineVaccine efficacyVaccine safety

Identifiers

PMID40997375
PMCPMC13246459

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.