Evidence map›Paper›PMID 40997225›Full record

ArticleAmerican journal of respiratory and critical care medicine2025

Acute Respiratory Distress Syndrome Molecular Phenotypes Have Distinct Lower Respiratory Tract Transcriptomes.

Aartik Sarma, Stephanie A Christenson, Beth Zha Shoshana, Angela Pisco Oliveira, Lucile P A Neyton, Eran Mick, Pratik Sinha, Jennifer G Wilson, Farzad Moazed, Aleksandra Leligdowicz and 24 more

Abstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Moving from Critical Illness Syndromes toward Biologic Molecular Endotypes: Making Progress.American journal of respiratory and critical care medicine · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors.

Aartik SarmaDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine.ORCID 0000-0002-7508-7345
Stephanie A ChristensonDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine.
Beth Zha ShoshanaDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine.
Angela Pisco OliveiraChan Zuckerberg Biohub, San Francisco, California.
Lucile P A NeytonDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine.ORCID 0000-0003-1273-2228
Eran MickDivision of Infectious Diseases, and.ORCID 0000-0002-7299-808X
Pratik SinhaDepartment of Anesthesia, Washington University in St. Louis, St. Louis, Missouri.
Jennifer G WilsonDepartment of Emergency Medicine, Stanford University School of Medicine, and.
Farzad MoazedDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine.
Aleksandra LeligdowiczCardiovascular Research Institute.
Manoj V MaddaliDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, California.
Emily R SiegelSchool of Medicine.
Zoe M LyonSchool of Medicine.
Sidney Haller CarrilloDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine.
Hanjing ZhouDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine.
Alejandra JaureguiDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine.
Rajani GhaleDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine.
Saharai CalderaChan Zuckerberg Biohub, San Francisco, California.
Paula Serpa HayakawaDivision of Infectious Diseases, and.
Thomas DeissDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine.
Christina LoveChan Zuckerberg Biohub, San Francisco, California.
Ashley ByrneChan Zuckerberg Biohub, San Francisco, California.
Katrina L KalantarChan Zuckerberg Biohub, San Francisco, California.
Joseph L DeRisiChan Zuckerberg Biohub, San Francisco, California.
David J ErleCardiovascular Research Institute.ORCID 0000-0002-2171-0648
Matthew F KrummelBakar ImmunoX Initiative.
Kirsten N KangelarisDivision of Hospital Medicine, and.
Carolyn M HendricksonDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Zuckerberg San Francisco General Hospital and Trauma Center.
Prescott G WoodruffDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine.
Michael A MatthayDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine.
Lieuwe D J BosIntensive Care, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Charles R LangelierDivision of Infectious Diseases, and.
Carolyn S CalfeeDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine.
COMET Consortium

Funding

Precision Medicine in the Acute Respiratory Distress SyndromeR35HL140026 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2018 to 2024
$6.8M
Precision Medicine in Sepsis with Critical IllnessR35GM142992 · NIGMS · WASHINGTON UNIVERSITY · PI Pratik Sinha · 2021 to 2026
$2.4M
Integrated Host/Microbe Metagenomics to Improve Lower Respiratory Tract Infection Diagnosis in Critically Ill ChildrenR01HL155418 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANGELIER, CHARLES · 2021 to 2024
$1.6M
Evolution and resolution of ARDS molecular phenotypesK23HL163491 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aartik Sarma · 2023 to 2026
$750k
ARDS Endotypes: Expanded Analysis of Clinical and Biological Phenotypes and Evolution Over TimeK24HL133390 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2016 to 2017
$241k
Transcriptomic signatures of airway inflammation in acute respiratory diseasesF32HL151117 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SARMA, AARTIK · 2020 to 2022
$206k
Chan Zuckerberg InitiativeGenentechNational Institute of Allergy and Infectious Diseases U19AI1077439NHLBI NIH HHS 5K24HL133390NHLBI NIH HHS 5R01HL155418NHLBI NIH HHS F32 HL151117NHLBI NIH HHS F32HL151117NHLBI NIH HHS K23 HL163491NHLBI NIH HHS K23HL163491NHLBI NIH HHS K24 HL133390NHLBI NIH HHS R01 HL155418NHLBI NIH HHS R35 HL140026NHLBI NIH HHS R35HL140026NIGMS NIH HHS R35 GM142992
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19Respiratory Distress SyndromeTranscriptomeAdultAgedFemaleHumansMaleMiddle AgedPhenotypeSARS-CoV-2ARDSmolecular phenotypesprecision medicineRNA sequencing

Identifiers

PMID40997225
PMCPMC12700240

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.